Konisky J, Tokuda H
Zentralbl Bakteriol Orig A. 1979 Jun;244(1):105-20.
Addition of colicins Ia, E1 or K to sensitive Escherichia coli leads to inhibition of macromolecular synthesis and an uncoupling of electron transport from active transport. Recent results indicate that these colicins affect energy metabolism by interacting directly with the cytoplasmic membrane. This results in a transmembrane flow of ions leading to membrane depolarization. It is proposed that the function of the outer membrane colicin receptor is to mediate access of the colicin molecule to the cytoplasmic membrane.
向敏感的大肠杆菌中添加大肠菌素Ia、E1或K会导致大分子合成受到抑制，以及电子传递与主动运输解偶联。最近的结果表明，这些大肠菌素通过直接与细胞质膜相互作用来影响能量代谢。这导致离子跨膜流动，进而引起膜去极化。有人提出，外膜大肠菌素受体的功能是介导大肠菌素分子进入细胞质膜。
