Mendas Inès, Gastaldi Stéphane, Suppo Jean-Simon
Aix Marseille Univ, CNRS, ICR, Marseille, France.
Molecules. 2024 May 22;29(11):2442. doi: 10.3390/molecules29112442.
-1-amino-2-indanol is an important building block in many areas of chemistry. Indeed, this molecule is currently used as skeleton in many ligands (BOX, PyBOX…), catalysts and chiral auxiliaries. Moreover, it has been incorporated in numerous bioactive structures. The major issues during its synthesis are the control of -selectivity, for which various strategies have been devised, and the enantioselectivity of the reaction. This review highlights the various methodologies implemented over the last few decades to access -1-amino-2-indanol in racemic and enantioselective manners. In addition, the various substitution patterns on the aromatic ring and their preparations are listed.
-1-氨基-2-茚醇是化学诸多领域中的重要结构单元。实际上,该分子目前在许多配体(BOX、PyBOX等)、催化剂和手性助剂中用作骨架。此外,它已被纳入众多生物活性结构中。其合成过程中的主要问题是控制α-选择性(针对此已设计出各种策略)以及反应的对映选择性。本综述着重介绍了过去几十年中以消旋和对映选择性方式制备α-1-氨基-2-茚醇所采用的各种方法。此外,还列出了芳环上的各种取代模式及其制备方法。