Mukhtarova Kymbat, Nurimanov Chingiz, Zholdybayeva Elena, Makhambetov Yerbol, Akshulakov Serik
National Center for Biotechnology, 13/5, Kurgalzhynskoye Road, Astana 010000, Kazakhstan.
Department of Vascular and Functional Neurosurgery, National Center for Neurosurgery, 34/1 Turan Avenue, Astana 010000, Kazakhstan.
Diagnostics (Basel). 2024 May 22;14(11):1077. doi: 10.3390/diagnostics14111077.
Arteriovenous malformations (AVMs) are abnormal tangles of arteries and veins that connect directly without an intervening capillary bed. Epileptic seizures are the second most common symptom in patients with brain AVMs, occurring in 30 to 50% of cases. However, the exact mechanism of epileptic seizure development in AVMs remains unclear. In this study, we aimed to investigate the factors associated with epileptic seizures in patients with brain arteriovenous malformation (AVMs) in Kazakhstan.
A case-control study was conducted, which included 163 patients diagnosed with brain AVMs. Demographic and clinical data were collected and analyzed, and multivariate logistic regression was built to assess the factors associated with seizures in brain AVMs.
from this rupture of vessels OR = 0.36 95% CI (0.14-0.91, a medium-to-high Spetzler-Martin score (III-V) OR = 6.16 (2.14-17.69) and OR = 3.05 (1.08-8.68), respectively), location in brain cortex (frontal lobe OR = 6.16 (2.04-18.54), parietal lobe OR = 9.37 (3.26-26.91), temporal lobe OR = 4.57 (1.56-13.36), occipital lobe OR = 0.27 (0.08-0.91), and the presence of hemiparesis OR = 0.12 (0.02-0.66) in adverse outcomes were statistically significantly associated with the presence of epileptic seizures in brain arteriovenous malformations patients.
To conclude, this contributed to model factors associated with brain arteriovenous malformations that are linked to epileptic seizures.
动静脉畸形（AVM）是动脉和静脉的异常缠结，它们直接相连，中间没有毛细血管床。癫痫发作是脑动静脉畸形患者的第二常见症状，发生率为30%至50%。然而，动静脉畸形中癫痫发作发展的确切机制仍不清楚。在本研究中，我们旨在调查哈萨克斯坦脑动静脉畸形（AVM）患者癫痫发作的相关因素。
进行了一项病例对照研究，纳入了163例诊断为脑AVM的患者。收集并分析了人口统计学和临床数据，并建立了多因素逻辑回归模型以评估与脑AVM癫痫发作相关的因素。
血管破裂导致癫痫发作的比值比（OR）=0.36，95%置信区间（CI）为（0.14 - 0.91）；中等至高Spetzler-Martin评分（III - V级）导致癫痫发作的OR分别为6.16（2.14 - 17.69）和3.05（1.08 - 8.68）；位于脑皮质（额叶OR = 6.16（2.04 - 18.54），顶叶OR = 9.37（3.26 - 26.91），颞叶OR = 4.57（1.56 - 13.36），枕叶OR = 0.27（0.08 - 0.91））以及存在偏瘫（OR = 0.12（0.02 - 0.66））与脑动静脉畸形患者癫痫发作的不良结局在统计学上显著相关。
总之，这有助于建立与脑动静脉畸形相关且与癫痫发作有关的模型因素。
