Edu Andrei Vicențiu, Pahomeanu Mihai Radu, Ghiță Andreea Irina, Constantinescu Dalia Ioana, Grigore Daniela Gabriela, Bota Andreea Daniela, Luta-Dumitrașcu Daniela Maria, Țieranu Cristian George, Negreanu Lucian
Faculty of Medicine, Carol Davila University of Medicine and Pharmacy Bucharest, 050474 Bucharest, Romania.
Internal Medicine and Gastroenterology Department, University Emergency Hospital of Bucharest, 050098 Bucharest, Romania.
Diagnostics (Basel). 2024 May 26;14(11):1105. doi: 10.3390/diagnostics14111105.
(1) Background: Hypertriglyceridemia (HTG) is a well-known metabolic condition associated with an increased risk of acute pancreatitis. In this study, we tried to establish whether there are any significant disparities concerning recurrence rate, intensive care unit (ICU) admission, hospital (ICU and total) length of stay (LoS), morphology, severity and age between HTG-induced acute pancreatitis and any other known cause of pancreatitis (OAP). (2) Methods: The research was a retrospective unicentric cohort study, using information from the Bucharest Acute Pancreatitis Index (BUC-API) registry, a database of 1855 consecutive cases of acute pancreatitis. (3) Results: We found a weak association between HTG-AP and recurrence. The HTG-AP patients were younger, with a median of 44.5 years, and had a longer ICU stay than the OAP patients. In addition, we identified that the HTG-AP patients were more likely to develop acute peripancreatic fluid collection (APFC), to be admitted in ICU, to have a more severe course of disease and to be cared for in a gastroenterology ward. (4) Conclusions: Hypertriglyceridemia-induced APs have a more severe course. The typical patient with HTG-AP is a middle-aged male, with previous episodes of AP, admitted in the gastroenterology ward, with a longer ICU stay and longer length of hospitalization, more likely to evolve in a severe acute pancreatitis (SAP) and with a higher probability of developing APFC.
（1）背景：高甘油三酯血症（HTG）是一种众所周知的代谢状况，与急性胰腺炎风险增加相关。在本研究中，我们试图确定在HTG诱发的急性胰腺炎与任何其他已知胰腺炎病因（OAP）之间，在复发率、重症监护病房（ICU）收治情况、住院（ICU和总住院）时长、形态、严重程度和年龄方面是否存在任何显著差异。（2）方法：该研究为回顾性单中心队列研究，使用来自布加勒斯特急性胰腺炎指数（BUC - API）登记处的信息，这是一个包含1855例连续急性胰腺炎病例的数据库。（3）结果：我们发现HTG - AP与复发之间存在微弱关联。HTG - AP患者更年轻，中位年龄为44.5岁，且在ICU的停留时间比OAP患者更长。此外，我们发现HTG - AP患者更有可能发生急性胰周液体积聚（APFC），更有可能入住ICU，疾病进程更严重，且在胃肠病科病房接受治疗。（4）结论：HTG诱发的急性胰腺炎病程更严重。HTG - AP的典型患者是中年男性，既往有急性胰腺炎发作史，入住胃肠病科病房，在ICU停留时间更长，住院时间更长，更有可能发展为重症急性胰腺炎（SAP），且发生APFC的可能性更高。
