Fan Zhengyang, Li Jianing, Wu Dong
Department of Gastroenterology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing.
Department of Gastroenterology, People's Hospital of Xizang Autonomous Region, Lhasa.
Curr Opin Gastroenterol. 2025 Sep 1;41(5):348-354. doi: 10.1097/MOG.0000000000001123. Epub 2025 Jul 17.
This review aims to summarize the recent developments in hypertriglyceridemic acute pancreatitis (HTG-AP) research in China, focusing on its increasing prevalence, pathophysiology, prognosis, and novel treatment strategies, emphasizing the relevance of these findings in clinical practice and research.
Recent studies have highlighted a rising incidence of HTG-AP in China, especially among young males, linked to dietary and lifestyle changes. Key research has identified lipoprotein metabolism abnormalities and genetic factors as predictors of recurrence. Advances in treatment include the combination of low-molecular-weight heparin, insulin, and plasma exchange, showing improved outcomes compared to traditional methods. Additionally, the use of traditional Chinese medicine has shown promise in managing inflammation and improving patient recovery.
These findings emphasize the importance of early diagnosis, personalized treatment strategies, and integrated approaches in managing HTG-AP. Chinese research has made significant strides in understanding the pathophysiology and treatment of HTG-AP, which may influence both national healthcare strategies and global management of the condition.
本综述旨在总结中国高甘油三酯性急性胰腺炎（HTG-AP）研究的最新进展，重点关注其发病率上升情况、病理生理学、预后及新型治疗策略，强调这些研究结果在临床实践和研究中的相关性。
近期研究突出了中国HTG-AP发病率的上升，尤其是在年轻男性中，这与饮食和生活方式的改变有关。关键研究已确定脂蛋白代谢异常和遗传因素为复发的预测指标。治疗方面的进展包括低分子量肝素、胰岛素和血浆置换的联合应用，与传统方法相比显示出更好的疗效。此外，中药的使用在控制炎症和促进患者康复方面已显示出前景。
这些发现强调了早期诊断、个性化治疗策略以及综合方法在管理HTG-AP中的重要性。中国在理解HTG-AP的病理生理学和治疗方面取得了重大进展，这可能会影响国家医疗保健策略以及全球对该疾病的管理。
