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通过悬浮火焰喷涂制备的用于抗菌应用的pH响应性聚己内酯-过氧化铜复合涂层

A pH-Responsive Polycaprolactone-Copper Peroxide Composite Coating Fabricated via Suspension Flame Spraying for Antimicrobial Applications.

作者信息

Cui Tingting, Zhou Daofeng, Zhang Yu, Kong Decong, Wang Zhijuan, Han Zhuoyue, Song Meiqi, Aimaier Xierzhati, Dan Yanxin, Zhang Botao, Li Hua

机构信息

Cixi Biomedical Research Institute, Wenzhou Medical University, Wenzhou 325035, China.

Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.

出版信息

Materials (Basel). 2024 Jun 1;17(11):2666. doi: 10.3390/ma17112666.

DOI:10.3390/ma17112666
PMID:38893930
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11173732/
Abstract

In this study, a pH-responsive polycaprolactone (PCL)-copper peroxide (CuO) composite antibacterial coating was developed by suspension flame spraying. The successful synthesis of CuO nanoparticles and fabrication of the PCL-CuO composite coatings were confirmed by microstructural and chemical analysis. The composite coatings were structurally homogeneous, with the chemical properties of PCL well maintained. The acidic environment was found to effectively accelerate the dissociation of CuO, allowing the simultaneous release of Cu and HO. Antimicrobial tests clearly revealed the enhanced antibacterial properties of the PCL-CuO composite coating against both and under acidic conditions, with a bactericidal effect of over 99.99%. This study presents a promising approach for constructing pH-responsive antimicrobial coatings for biomedical applications.

摘要

在本研究中，通过悬浮火焰喷涂制备了一种pH响应性聚己内酯（PCL）-过氧化铜（CuO）复合抗菌涂层。通过微观结构和化学分析证实了CuO纳米颗粒的成功合成以及PCL-CuO复合涂层的制备。复合涂层结构均匀，PCL的化学性质得到良好保持。发现酸性环境能有效加速CuO的解离，使Cu和HO同时释放。抗菌测试清楚地表明，PCL-CuO复合涂层在酸性条件下对 和 均具有增强的抗菌性能，杀菌效果超过99.99%。本研究为构建用于生物医学应用的pH响应性抗菌涂层提供了一种有前景的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b2/11173732/be80d1834c95/materials-17-02666-g012.jpg
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