Pediatric Hematology and Oncology Department, Vall Hebron Barcelona Hospital Campus, Barcelona, Spain.
Pediatric Hemato-Oncology Department, Hospital Universitario Son Espases, Mallorca, Spain.
Pediatr Transplant. 2024 Aug;28(5):e14810. doi: 10.1111/petr.14810.
Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy. In the last few years, after the publication of the consensus guidelines, with refined diagnostic criteria and improved awareness, FPIES is diagnosed with increased frequency. However, despite having a background of immune dysregulation, this complication has just been described once in the posttransplant setting, in an adult patient. To the best of our knowledge, there are no reports of pediatric patients developing FPIES after a hematopoietic stem cell transplant (HCT).
Retrospective review of a pediatric patient who developed severe FPIEs after a HCT.
In this case report, the clinical presentation and diagnosis challenges of a pediatric patient who developed severe FPIES after HCT are described. The patient developed severe vomiting, diarrhea, lethargy, and shock and required admission to the pediatric intensive care unit in three occasions before the diagnosis was made.
To the best of our knowledge, this is the first report of severe FPIES post-HCT in a pediatric patient. Physicians who are looking after pediatric patients in the post-HCT setting need to be aware of this possibility and include this entity in the differential diagnosis in order to reduce its associated morbidity.
食物蛋白诱导的小肠结肠炎综合征（FPIES）是一种非 IgE 介导的食物过敏。在最近几年，随着共识指南的发表，以及诊断标准的细化和认识的提高，FPIES 的诊断频率有所增加。然而，尽管存在免疫失调的背景，但这种并发症仅在成年患者的移植后环境中被描述过一次。据我们所知，尚无造血干细胞移植（HCT）后儿童患者发生 FPIES 的报道。
回顾性分析一名 HCT 后发生严重 FPIES 的儿科患者。
在本病例报告中，描述了一名 HCT 后发生严重 FPIES 的儿科患者的临床表现和诊断挑战。该患者在确诊前曾三次因严重呕吐、腹泻、嗜睡和休克而入住儿科重症监护病房。
据我们所知，这是首例 HCT 后严重 FPIES 的儿科病例报告。在 HCT 后照护儿科患者的医生需要意识到这种可能性，并将其纳入鉴别诊断，以降低其相关发病率。
