Wu Deqi, Pan Chi, Hu Yangying, Shi Zhijie, Zhou Yankun, Xiao Min
Department of Thyroid and Breast Diagnosis and Treatment Center, Shulan (Hangzhou) Hospital, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China.
Department of Breast Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Oncol. 2024 Jun 4;14:1366900. doi: 10.3389/fonc.2024.1366900. eCollection 2024.
Breast cancer is a significant public health issue, exhibiting the most pronounced occurrence and fatality rates among malignant neoplasms globally. Targeted therapy is a medical intervention that focuses on specific molecular markers. This study aims to investigate and evaluate the current research trends and directions in the field of targeted therapy for breast cancer using bibliometric analysis.
The Web of Science database was utilized to retrieve relevant articles published between 2003 and 2022. The VOSviewer software and Bibliometrix package in the R language were employed to conduct co-occurrence and clustering analyses of authors, countries, institutions, journals, references, and the CiteSpace tool was utilized for keyword burst detection.
A total of 2,258 articles were included and the annual number of publications increased rapidly. The most prolific country on this topic was the USA (n=898, 39.77%) and the University of Texas MD Anderson Cancer Center published most papers (n=93). Dennis J. Slamon and Gabriel N. Hortobagyi stood out in the field, with Dennis J. Slamon leading in terms of co-citations(n=653) and Gabriel N. Hortobagyi topping the list in terms of published articles(n=18). The most productive journal was Breast Cancer Research and Treatment and the most cited journal was Journal of Clinical Oncology. The clustering of keywords indicated that the primary focus of researches in the past two decades was on the development and clinical evaluation of tumor-targeted drugs associated with the epidermal growth factor receptor (EGFR) family signaling pathway, and explored mechanisms related to biological behavior of breast cancer. Keywords co-occurrence and burst analysis identified current research hotspots and potential research trends.
This study employed bibliometric analysis to examine research on targeted therapy for breast cancer over a span of 20 years, and identified development trends of research and elucidated potential research trajectories in the domain of this topic. This study helps in the identification of prospective collaborators and partner institutions for researchers.
乳腺癌是一个重大的公共卫生问题，在全球恶性肿瘤中发病率和死亡率最为显著。靶向治疗是一种针对特定分子标志物的医学干预措施。本研究旨在通过文献计量分析来调查和评估乳腺癌靶向治疗领域的当前研究趋势和方向。
利用科学网数据库检索2003年至2022年发表的相关文章。使用VOSviewer软件和R语言中的Bibliometrix包对作者、国家、机构、期刊、参考文献进行共现和聚类分析，并利用CiteSpace工具进行关键词突现检测。
共纳入2258篇文章，年发表量迅速增加。在该主题上发文最多的国家是美国（n = 898，39.77%），德克萨斯大学MD安德森癌症中心发表的论文最多（n = 93）。丹尼斯·J·斯拉蒙（Dennis J. Slamon）和加布里埃尔·N·霍尔托巴吉（Gabriel N. Hortobagyi）在该领域表现突出，丹尼斯·J·斯拉蒙在共被引次数方面领先（n = 653），加布里埃尔·N·霍尔托巴吉在发表文章数量方面位居榜首（n = 18）。发文量最高的期刊是《乳腺癌研究与治疗》（Breast Cancer Research and Treatment），被引次数最多的期刊是《临床肿瘤学杂志》（Journal of Clinical Oncology）。关键词聚类表明，过去二十年研究的主要重点是与表皮生长因子受体（EGFR）家族信号通路相关的肿瘤靶向药物的研发和临床评估，并探索与乳腺癌生物学行为相关的机制。关键词共现和突现分析确定了当前的研究热点和潜在的研究趋势。
本研究采用文献计量分析方法，对20年来乳腺癌靶向治疗的研究进行了考察，确定了该主题领域的研究发展趋势，并阐明了潜在的研究轨迹。本研究有助于为研究人员识别潜在的合作对象和合作机构。
