Zhou Yi, Jiang Min, Li Xiaoyu, Shen Ke, Zong Hui, Lv Qing, Shen Bairong
Department of Breast Surgery and Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Sichuan, China.
Front Microbiol. 2024 Dec 9;15:1490007. doi: 10.3389/fmicb.2024.1490007. eCollection 2024.
The composition of the gut microbiome differs from that of healthy individuals and is closely linked to the progression and development of breast cancer. Recent studies have increasingly examined the relationship between microbial communities and breast cancer. This study analyzed the research landscape of microbiome and breast cancer, focusing on 736 qualified publications from the Web of Science Core Collection (WoSCC). Publications in this field are on the rise, with the United States leading in contributions, followed by China and Italy. Despite this strong output, the centrality value of China in this field is comparatively low at ninth, highlighting a gap between the quantity of research and its global impact. This pattern is repetitively observed in institutional contributions, with a predominance of Western institutes among the top contributors, underscoring a potential research quality gap in China. Keyword analysis reveals that research hotspots are focused on the effect of microbiome on breast cancer pathogenesis and tumor metabolism, with risk factors and metabolic pathways being the most interesting areas. Publications point to a shift toward anti-tumor therapies and personalized medicine, with clusters such as "anti-tumor" and "potential regulatory agent" gaining prominence. Additionally, intratumor bacteria studies have emerged as a new area of significant interest, reflecting a new direction in research. The University of Helsinki and Adlercreutz H are influential institutions and researchers in this field. Current trends in microbiome and breast cancer research indicate a significant shift toward therapeutic applications and personalized medicine. Strengthening international collaborations and focusing on research quality is crucial for advancing microbiome and breast cancer research.
肠道微生物群的组成与健康个体不同，且与乳腺癌的进展和发展密切相关。最近的研究越来越多地探讨了微生物群落与乳腺癌之间的关系。本研究分析了微生物组与乳腺癌的研究概况，重点关注来自科学网核心合集（WoSCC）的736篇合格出版物。该领域的出版物数量在不断增加，美国的贡献领先，其次是中国和意大利。尽管产出颇丰，但中国在该领域的中心性值相对较低，排在第九位，这凸显了研究数量与其全球影响力之间的差距。在机构贡献方面也反复观察到这种模式，顶级贡献者中西方机构占主导地位，这凸显了中国在潜在研究质量方面的差距。关键词分析表明，研究热点集中在微生物组对乳腺癌发病机制和肿瘤代谢的影响上，风险因素和代谢途径是最受关注的领域。出版物指出了向抗肿瘤疗法和个性化医学的转变，诸如“抗肿瘤”和“潜在调节因子”等聚类变得突出。此外，肿瘤内细菌研究已成为一个备受关注的新领域，反映了研究方向的转变。赫尔辛基大学和阿德勒克雷茨H是该领域有影响力的机构和研究人员。微生物组与乳腺癌研究的当前趋势表明，正朝着治疗应用和个性化医学发生重大转变。加强国际合作并注重研究质量对于推进微生物组与乳腺癌研究至关重要。
