模糊基因：挪威大鼠对华法林耐药的一种遗传标记。

Fuzzy: a genetic marker for warfarin resistance in the Norway rat.

作者信息

Greaves J H, Ayres P B

出版信息

Lab Anim. 1985 Apr;19(2):145-7. doi: 10.1258/002367785780942723.

Abstract

No recombination was observed between fuzzy (fz) and warfarin resistance (Rww) in 245 rats from a backcross test for linkage. This locates fz very close to Rw in linkage group I. The map position established for fz makes this allele particularly suitable for use in combination with p (pink-eyed dilution) for linkage tests in group I and as a genetic marker for the Rw locus in studies of warfarin resistance. The map position of fz in the rat corresponds to that of fr (frizzy) in the mouse, suggesting homology between these loci in the 2 species.

摘要

在一项用于连锁分析的回交试验中，对245只大鼠进行检测，未观察到模糊（fz）与对华法林耐药性（Rww）之间发生重组。这表明fz在连锁群I中与Rw位置非常接近。确定的fz图谱位置使得该等位基因特别适合与p（粉红眼稀释基因）联合用于连锁群I的连锁测试，并在对华法林耐药性的研究中作为Rw位点的遗传标记。大鼠中fz的图谱位置与小鼠中fr（卷曲）的图谱位置相对应，这表明这两个物种的这些基因座之间具有同源性。