Manners Jody, Jusuf Emily, Parikh Gunjan Y, Gasior Maciej, Vaitkevicius Henrikas, Morris Nicholas A
Department of Neurology, Program in Trauma, University of Maryland School of Medicine, Baltimore, MD, USA.
Naval Medical Leader and Professional Development Command, Bethesda, MD, USA.
Neurohospitalist. 2024 Jul;14(3):327-331. doi: 10.1177/19418744241232181. Epub 2024 Feb 20.
We present a case of a 34-year-old man with epilepsy who developed super refractory status epilepticus in the setting of COVID-19 pneumonia in whom aggressive therapy with multiple parenteral, enteral, and non-pharmacologic interventions were utilized without lasting improvement in clinical examination or electroencephalogram (EEG). The patient presented with multiple recurrences of electrographic status epilepticus throughout a prolonged hospital stay. Emergency use authorization was obtained for intravenous ganaxolone, a neuroactive steroid that is a potent modulator of both synaptic and extrasynaptic GABA receptors. Following administration of intravenous ganaxolone according to a novel dosing paradigm, the patient showed sustained clinical and electrographic improvement.
我们报告了一例34岁的癫痫男性患者，该患者在新型冠状病毒肺炎背景下发展为超难治性癫痫持续状态，尽管采用了多种肠外、肠内和非药物干预的积极治疗，但临床检查或脑电图（EEG）均未得到持久改善。在漫长的住院期间，患者多次出现脑电图癫痫持续状态复发。静脉注射加奈索酮获得了紧急使用授权，加奈索酮是一种神经活性类固醇，是突触和突触外GABA受体的有效调节剂。按照一种新的给药方案给予静脉注射加奈索酮后，患者的临床和脑电图均持续改善。
