De Mauro Domenico, Meschini Cesare, Balato Giovanni, Ascione Tiziana, Festa Enrico, Bizzoca Davide, Moretti Biagio, Maccauro Giulio, Vitiello Raffaele
Department of Orthopedics and Rheumatological Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Department of Orthopedics and Geriatric Sciences, Catholic University of the Sacred Heart, Rome, Italy.
J Bone Jt Infect. 2024 Apr 30;9(2):137-142. doi: 10.5194/jbji-9-137-2024. eCollection 2024.
: Periprosthetic joint infections (PJIs) have emerged as a focal point in the realm of orthopedics, garnering widespread attention owing to the escalating incidence rates and the profound impact they impose on patients undergoing total joint arthroplasties (TJAs). Year after year, there has been a growing trend in the analysis of multiple risk factors, complication rates, and surgical treatments in the field. This study aims to illuminate the status of the sex-related differences in periprosthetic joint infections and advance research in this field. : A systematic review was carried out following the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. The final reference list comprised longitudinal studies (both retrospective and prospective) and randomized controlled trials. A sex-based analysis was conducted to assess differences between males and females. : A total of 312 studies were initially identified through online database searches and reference investigations. Nine studies were subsequently included in the review. Eight out of nine studies examined the risk of developing PJI after total joint replacement. Notably, only half of these studies demonstrated a statistically significant value, with a value , indicating a higher risk of infectious complications in males compared to females. : According to the current literature, there appears to be a propensity for males to develop periprosthetic joint infection after total joint arthroplasty at a higher rate than the female population. Enhancing sex-related analysis in this field is imperative for gathering more robust evidence and insights.
人工关节周围感染（PJIs）已成为骨科领域的一个焦点，由于其发病率不断上升以及对接受全关节置换术（TJAs）的患者产生的深远影响而受到广泛关注。年复一年，该领域对多种风险因素、并发症发生率和手术治疗的分析呈增长趋势。本研究旨在阐明人工关节周围感染中性别差异的现状，并推动该领域的研究进展。：按照系统评价和Meta分析的首选报告项目（PRISMA）指南进行了系统评价。最终的参考文献列表包括纵向研究（回顾性和前瞻性）和随机对照试验。进行了基于性别的分析，以评估男性和女性之间的差异。：通过在线数据库搜索和参考文献调查，最初共识别出312项研究。随后，9项研究被纳入综述。9项研究中有8项研究了全关节置换术后发生PJIs的风险。值得注意的是，这些研究中只有一半显示出具有统计学意义的值， 值为 ，表明男性发生感染性并发症的风险高于女性。：根据目前的文献，男性在全关节置换术后发生人工关节周围感染的倾向似乎高于女性人群。加强该领域与性别相关的分析对于收集更有力的证据和见解至关重要。
