Department of Oral and Maxillofacial Surgery, Harran University, Faculty of Dentistry, Sanliurfa, Turkiye.
Department of Periodontology, Harran University, Faculty of Dentistry, Sanliurfa, Turkiye.
Drug Des Devel Ther. 2024 Jun 14;18:2249-2256. doi: 10.2147/DDDT.S459125. eCollection 2024.
Recently, a lot of research has been done around the world to popularize the osseointegration of dental implants. In this study, it was investigated the effect of local zoledronic acid application on implants with machined (MAC), resorbable blast materials (RBM), sandblasted and acid-etched (SLA) surface implants integrated in rat tibias.
A total of 60 female Wistar rats weighing between 270 and 300 g were used in the study. The rats were passing divided into six classes: controls; MAC (n = 10), RBM (n = 10), SLA (n = 10), and local zoledronic acid (LZA) applied groups; LZA-MAC (n = 10), LZA-RBM (n=10) and LZA-SLA (n = 10) and implants were surgically placement into rat tibias in general anesthesia. After a four-week experimental period, the biomechanical bone implant connection level was determined with reverse torque analysis.
Osseointegration levels were detected highly in SLA and RBM surface compared with the machined surfaced implants in both control and treatment groups (p < 0.05). Additionally, local application of zoledronic acid in both three groups; implants increased the biomechanic osseointegration level compared with the controls (p < 0.05).
In this research, we observe that the local application of the zoledronic acid could increase the osseointegration, and RBM and SLA surface could be better than machined surfaced implants in terms of bone implant connection. In addition, local application of zoledronic acid may be a safer method than systemic application.
最近，全世界范围内进行了大量研究以推广种植牙的骨整合。在这项研究中，研究了局部唑来膦酸应用对机械加工（MAC）、可吸收爆炸材料（RBM）、喷砂酸蚀（SLA）表面种植体在大鼠胫骨中整合的种植体的影响。
本研究共使用了 60 只体重在 270 到 300 克之间的雌性 Wistar 大鼠。这些大鼠被随机分为六组：对照组；MAC（n = 10）、RBM（n = 10）、SLA（n = 10）和局部唑来膦酸（LZA）应用组；LZA-MAC（n = 10）、LZA-RBM（n = 10）和 LZA-SLA（n = 10），并在全身麻醉下将种植体手术植入大鼠胫骨。经过四周的实验期后，使用反向扭矩分析确定生物力学骨-种植体连接水平。
与对照组和治疗组的机械加工表面种植体相比，SLA 和 RBM 表面的种植体骨整合水平较高（p < 0.05）。此外，在三个治疗组中，局部应用唑来膦酸均能提高生物力学骨整合水平，与对照组相比（p < 0.05）。
在这项研究中，我们观察到局部应用唑来膦酸可以增加骨整合，并且 RBM 和 SLA 表面在骨-种植体连接方面可能优于机械加工表面种植体。此外，局部应用唑来膦酸可能比全身应用更安全。
