Biophysical aspects of gas bubbles in blood.

The widespread use of bubble oxygenators during cardiopulmonary bypass has raised questions concerning the production and introduction of gaseous microemboli (GME) into patients. An understanding of the complications associated with GME requires awareness of the biophysical and biochemical responses that occur between bubbles and blood. The production of GME as well as their interactions with each other and with blood products are examined. These interactions can influence the data collected from Doppler ultrasound devices and the development of organ dysfunction.