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前列腺活检时疼痛和不适的风险因素及当代管理选择。

Risk Factors and Contemporary Management Options for Pain and Discomfort Experienced During a Prostate Biopsy.

机构信息

Department of Urology, Yale School of Medicine, New Haven, CT, USA.

Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.

出版信息

Curr Urol Rep. 2024 Oct;25(10):243-252. doi: 10.1007/s11934-024-01220-w. Epub 2024 Jun 19.

DOI:10.1007/s11934-024-01220-w
PMID:38896314
Abstract

PURPOSE OF REVIEW

Prostate fusion biopsy, an innovative imaging modality for diagnosing prostate cancer, presents certain challenges for patients including discomfort and emotional distress, leading to nonadherence to treatment and follow-ups. To inform clinicians and offer pain relief alternatives to patients, this review delves into the risk factors for increased pain and modern management options to alleviate pain during prostate biopsy.

RECENT FINDINGS

Individual responses to pain vary, and the overall experience of pain during a prostate biopsy has been contributed to numerous factors such as patient age, prostate volume, previous biopsy experience, and more. As a result, several strategies aim to mitigate pain during in-office procedures. Notably, techniques including pharmacological analgesics, hand holding, heating pads, entertainment/virtual reality, and distraction have shown significant efficacy. Existing studies explore risk factors influencing pain intensity during prostate biopsy and effective pain management strategies. This review consolidates available information to guide clinicians in enhancing patient comfort and thus, encourage surveillance adherence.

摘要

目的综述

前列腺融合活检作为一种创新性的影像学诊断前列腺癌的方法,给患者带来了一些挑战,包括不适和情绪困扰,导致治疗和随访的不依从。为了告知临床医生并为患者提供疼痛缓解的替代方案,本综述深入探讨了增加疼痛的风险因素和缓解前列腺活检过程中疼痛的现代管理选择。

最近的发现

个体对疼痛的反应不同,前列腺活检过程中的整体疼痛体验归因于许多因素,如患者年龄、前列腺体积、既往活检经验等。因此,有几种策略旨在减轻门诊手术中的疼痛。值得注意的是,包括药物镇痛、手握手、加热垫、娱乐/虚拟现实和分散注意力在内的技术已显示出显著的疗效。现有研究探讨了影响前列腺活检过程中疼痛强度的风险因素和有效的疼痛管理策略。本综述整合了现有信息,以指导临床医生提高患者舒适度,从而鼓励他们进行监测随访。

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本文引用的文献

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Shifting to transperineal prostate biopsy: A narrative review.转向经会阴前列腺活检:一项叙述性综述。
Prostate Int. 2024 Mar;12(1):10-14. doi: 10.1016/j.prnil.2023.11.003. Epub 2023 Nov 30.
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Emotion-centered versus fact-centered medical information to alleviate pain and anxiety in prostate biopsy: A randomized trial.以情绪为中心与以事实为中心的医疗信息对缓解前列腺活检疼痛和焦虑的作用:一项随机试验。
Prostate. 2024 Mar;84(4):389-394. doi: 10.1002/pros.24659. Epub 2023 Dec 20.
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Comparison of procedural anxiety and pain associated with conventional transrectal ultrasound prostate biopsy to magnetic resonance imaging-ultrasound fusion-guided biopsy: a prospective cohort trial.
比较传统经直肠超声前列腺活检与磁共振成像-超声融合引导活检的操作焦虑和疼痛:一项前瞻性队列研究。
Prostate Cancer Prostatic Dis. 2024 Jun;27(2):294-299. doi: 10.1038/s41391-023-00760-5. Epub 2023 Nov 25.
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Practical Use of Self-Adjusted Nitrous Oxide During Transrectal Prostate Biopsy: A Double-Blind Randomized Controlled Trial.经直肠前列腺穿刺活检中自调整一氧化二氮的实际应用:一项双盲随机对照试验。
J Urol. 2024 Feb;211(2):214-222. doi: 10.1097/JU.0000000000003789. Epub 2023 Nov 20.
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A brief mind-body intervention to reduce pain and anxiety during prostate needle biopsy: a clinically integrated randomized controlled trial with 2-staged consent.一种简短的心身干预措施,可减少前列腺穿刺活检期间的疼痛和焦虑:具有 2 阶段同意的临床整合随机对照试验。
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Patient Reported Outcomes of Transperineal Prostate Biopsy With Tumescent Local Anesthesia.经皮会阴前列腺穿刺活检术联合肿胀局部麻醉的患者报告结局。
Urology. 2023 Dec;182:33-39. doi: 10.1016/j.urology.2023.09.010. Epub 2023 Sep 22.
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Perineal nerve block versus periprostatic block for patients undergoing transperineal prostate biopsy (APROPOS): a prospective, multicentre, randomised controlled study.经会阴前列腺活检患者的会阴神经阻滞与前列腺周围阻滞(APROPOS):一项前瞻性、多中心、随机对照研究。
EClinicalMedicine. 2023 Mar 23;58:101919. doi: 10.1016/j.eclinm.2023.101919. eCollection 2023 Apr.
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The Severity of Pain in Prostate Biopsy Depends on the Biopsy Sector.前列腺活检疼痛的严重程度取决于活检部位。
J Pers Med. 2023 Feb 27;13(3):431. doi: 10.3390/jpm13030431.
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Comparison of intrarectal heated lidocaine gel and periprostatic nerve block for pain control in transrectal ultrasound-guided prostate biopsy: A randomized controlled non-inferiority trial.经直肠超声引导下前列腺活检中直肠内加热利多卡因凝胶与前列腺周围神经阻滞用于疼痛控制的比较:一项随机对照非劣效性试验。
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The effect of music therapy on anxiety and pain in patients undergoing prostate biopsy: A systematic review and meta-analysis.音乐疗法对前列腺活检患者焦虑和疼痛的影响:系统评价和荟萃分析。
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