金催化通过分子内区域选择性7-外向-双环化反应形成芳基稠合的吡唑并恶唑并氮杂卓。
Gold-catalyzed formation of aryl-fused pyrazolooxazepines via intramolecular regioselective 7-exo-dig cyclization.
作者信息
Guduru Ravinder, Mangina N S V M Rao, Sridhar Balasubramanian, Karunakar Galla V
机构信息
Division of Fluoro and Agrochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500007, India.
出版信息
Org Biomol Chem. 2019 Mar 6;17(10):2809-2817. doi: 10.1039/c8ob03157f.
An efficient method was developed for the synthesis of substituted aryl-fused pyrazolooxazepines from ortho-O-propargyl aryl pyrazoles by gold catalysis. In this organic transformation a new C-N bond was formed regioselectively via 7-exo-dig cyclization. Moderate to good yields of aryl-fused pyrazolooxazepine derivatives were obtained with significant molecular complexity in one-pot.
开发了一种通过金催化从邻位-O-炔丙基芳基吡唑合成取代芳基稠合吡唑并恶唑嗪的有效方法。在这种有机转化中，通过7-外向-双环化区域选择性地形成了新的C-N键。一锅法以中等至良好的产率得到了具有显著分子复杂性的芳基稠合吡唑并恶唑嗪衍生物。
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