Guduru Ravinder, Mangina N S V M Rao, Sridhar Balasubramanian, Karunakar Galla V
Division of Fluoro and Agrochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500007, India.
Org Biomol Chem. 2019 Mar 6;17(10):2809-2817. doi: 10.1039/c8ob03157f.
An efficient method was developed for the synthesis of substituted aryl-fused pyrazolooxazepines from ortho-O-propargyl aryl pyrazoles by gold catalysis. In this organic transformation a new C-N bond was formed regioselectively via 7-exo-dig cyclization. Moderate to good yields of aryl-fused pyrazolooxazepine derivatives were obtained with significant molecular complexity in one-pot.
开发了一种通过金催化从邻位-O-炔丙基芳基吡唑合成取代芳基稠合吡唑并恶唑嗪的有效方法。在这种有机转化中，通过7-外向-双环化区域选择性地形成了新的C-N键。一锅法以中等至良好的产率得到了具有显著分子复杂性的芳基稠合吡唑并恶唑嗪衍生物。
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