Research Center for Translational Medicine, Shanghai East Hospital affiliated to Tongji University School of Medicine; The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200092, China.
ACS Nano. 2024 Jul 2;18(26):16853-16866. doi: 10.1021/acsnano.4c02546. Epub 2024 Jun 19.
The precise modulation of electrical activity in specific neuronal populations is paramount for rectifying abnormal neurological functions and is a critical element in the therapeutic arsenal for neurological disorders. However, achieving a balance between minimal invasiveness and robust neuroprotection poses a considerable challenge. Herein, we present a nanoneuromodulation strategy integrating neuroprotective features to effectively address epilepsy with minimal invasiveness and enable wireless functionality. Strategically engineered nanotransducer, adorned with platinum (Pt) decoration with titanium disulfide (TiS) (TiS/Pt), enables precise modulation of neuronal electrical activity and , ensuring exceptional temporal fidelity under millisecond-precision near-infrared (NIR) light pulses irradiation. Concurrently, TiS/Pt showcase a pronounced enhancement in enzyme-mimicking activity, offering a robust defense against oxidative neurological injury . Nanotransducer-enabled wireless neuromodulation with biocatalytic neuroprotective capacity is highly effective in alleviating epileptic high-frequency neural activity and diminishing oxidative stress levels, thereby restoring redox equilibrium. This integrated therapeutic approach reduces the severity of epilepsy, demonstrating minimal invasiveness and obviating the requirements for genetic manipulation and optical fiber implantation, while providing an alternative avenue for neurological disorder treatment.
精确调节特定神经元群体的电活动对于纠正异常神经功能至关重要，是治疗神经紊乱的重要手段之一。然而，在最小侵入性和强大神经保护之间取得平衡是一项巨大的挑战。在此，我们提出了一种纳米神经调节策略，整合了神经保护特性，以最小的侵入性有效地治疗癫痫，并实现无线功能。经过策略设计的纳米换能器，表面装饰有铂（Pt）和二硫化钛（TiS）（TiS/Pt），可实现神经元电活动的精确调节，确保在毫秒级精度的近红外（NIR）光脉冲照射下具有出色的时间保真度。同时，TiS/Pt 表现出显著增强的酶模拟活性，为抵抗氧化神经损伤提供了强大的保护。具有生物催化神经保护能力的纳米换能器无线神经调节可有效缓解癫痫高频神经活动和降低氧化应激水平，从而恢复氧化还原平衡。这种综合治疗方法可减轻癫痫的严重程度，具有最小的侵入性，无需进行基因操作和光纤植入，为神经紊乱的治疗提供了另一种选择。
