Shekhawat Dolat Singh, Singh Kuldeep, Singh Pratibha, Vyas Varuna, Varthya Shoban Babu, Sharma Praveen
Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, India.
Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Jodhpur, India.
Nutr Neurosci. 2025 Mar;28(3):263-272. doi: 10.1080/1028415X.2024.2366649. Epub 2024 Jun 19.
Vitamin D is involved in several processes related to the development of neuronal and non-neuronal cells. There is a possible link between maternal vitamin D status in pregnancy and delayed neurocognitive development in the offspring. The aim of the study was to explore the association of maternal and cord blood vitamin D levels with infants' neurodevelopment at 6 and 9 months of age.
A cohort study was conducted in western Rajasthan, India. Maternal and cord blood samples were collected at the time of delivery. Serum 25(OH)-vitamin D levels were measured in both. Infant neurodevelopment was assessed at 6 and 9 months of age in six domains namely cognitive, receptive language, expressive language, fine motor, gross motor and social-emotional using the Bayley Scale of Infant Development- III (BSID-III).
A total of 175 mother-child pairs were enrolled. Among the mothers taking part in this study, 7.3% had deficient and 59.09% had insufficient levels of serum 25(OH) vitamin D during the third trimester of their pregnancy. Maternal and cord blood serum 25-OH vitamin D levels were 18.86 ± 8.53 ng/mL and 17.39 ± 8.87 ng/mL, respectively, and there was a significant correlation (r = 0.9778, = 0.000) between levels of vitamin D. Based on the repeated measures ANOVA, post hoc Tukey's HSD test, maternal vitamin D levels had a significant relationship ( = 0.047) to the cognitive development of infants at 6 months of age. Furthermore, cord serum vitamin D levels showed a significant association ( = 0.023 and = 0.010) with the social-emotional development of the infant at the age of 6 and 9 months.
Maternal and cord serum 25-OH vitamin D deficiency was significantly associated with the cognitive and social-emotional development of infants.
维生素D参与神经元和非神经元细胞发育的多个过程。孕期母亲的维生素D状态与后代神经认知发育延迟之间可能存在联系。本研究的目的是探讨母亲和脐带血维生素D水平与婴儿6个月和9个月时神经发育的关联。
在印度拉贾斯坦邦西部进行了一项队列研究。分娩时采集母亲和脐带血样本。同时测量两者的血清25(OH)-维生素D水平。使用贝利婴儿发育量表第三版（BSID-III）在6个月和9个月时从认知、接受性语言、表达性语言、精细运动、大运动和社会情感六个领域评估婴儿神经发育。
共纳入175对母婴。参与本研究的母亲中，7.3%在孕期第三个月血清25(OH)维生素D水平不足，59.09%水平不够。母亲和脐带血血清25-OH维生素D水平分别为18.86±8.53 ng/mL和17.39±8.87 ng/mL，维生素D水平之间存在显著相关性（r = 0.9778，P = 0.000）。基于重复测量方差分析和事后Tukey's HSD检验，母亲维生素D水平与6个月大婴儿的认知发育有显著关系（P = 0.047）。此外，脐带血清维生素D水平与6个月和9个月大婴儿的社会情感发育有显著关联（P = 0.023和P = 0.010）。
母亲和脐带血清25-OH维生素D缺乏与婴儿的认知和社会情感发育显著相关。
