Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92617, USA.
Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92617, USA; University of Amsterdam, Amsterdam 1000 GG, The Netherlands.
Psychiatry Res Neuroimaging. 2024 Aug;342:111843. doi: 10.1016/j.pscychresns.2024.111843. Epub 2024 Jun 6.
Schizophrenia is associated with robust white matter (WM) abnormalities but influences of potentially confounding variables and relationships with cognitive performance and symptom severity remain to be fully determined. This study was designed to evaluate WM abnormalities based on diffusion tensor imaging (DTI) in individuals with schizophrenia, and their relationships with cognitive performance and symptom severity. Data from individuals with schizophrenia (SZ; n=138, mean age±SD=39.02±11.82; 105 males) and healthy controls (HC; n=143, mean age±SD=37.07±10.84; 102 males) were collected as part of the Function Biomedical Informatics Research Network Phase 3 study. Fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD) were compared between individuals with schizophrenia and healthy controls, and their relationships with neurocognitive performance and symptomatology assessed. Individuals with SZ had significantly lower FA in forceps minor and the left inferior fronto-occipital fasciculus compared to HC. FA in several tracts were associated with speed of processing and attention/vigilance and the severity of the negative symptom alogia. This study suggests that regional WM abnormalities are fundamentally involved in the pathophysiology of schizophrenia and may contribute to cognitive performance deficits and symptom expression observed in schizophrenia.
精神分裂症与强大的白质（WM）异常有关，但潜在混杂变量的影响及其与认知表现和症状严重程度的关系仍有待充分确定。本研究旨在评估精神分裂症个体的 WM 异常，并基于扩散张量成像（DTI）评估其与认知表现和症状严重程度的关系。精神分裂症个体（SZ；n=138，平均年龄±标准差=39.02±11.82；105 名男性）和健康对照组（HC；n=143，平均年龄±标准差=37.07±10.84；102 名男性）的数据是作为功能生物医学信息学研究网络第三阶段研究的一部分收集的。比较了精神分裂症个体和健康对照组之间的各向异性分数（FA）、轴向扩散系数（AD）、径向扩散系数（RD）和平均扩散系数（MD），并评估了它们与神经认知表现和症状学的关系。与 HC 相比，SZ 个体在小钳部和左侧下额枕束的 FA 明显降低。几个束的 FA 与处理速度和注意力/警觉性以及阴性症状言语贫乏的严重程度相关。本研究表明，区域性 WM 异常与精神分裂症的病理生理学密切相关，可能导致精神分裂症中观察到的认知表现缺陷和症状表达。
