Hines Lindsey A, Cannings-John Rebecca, Hawkins Jemma, Bonell Chris, Hickman Matthew, Zammit Stanley, Adara Linda, Townson Julia, White James
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; Department of Psychology, University of Bath, Bath, UK.
Centre for Trials Research, School of Medicine, Cardiff University, Cardiff, UK.
Drug Alcohol Depend. 2024 Aug 1;261:111359. doi: 10.1016/j.drugalcdep.2024.111359. Epub 2024 Jun 14.
In legal and illegal markets, high-potency cannabis (>10 % delta-9-tetrahydrocannabinol (THC)) is increasingly available. In adult samples higher-potency cannabis has been associated with mental health disorder but no studies have considered associations in adolescence.
A population-wide study compared no, low and high potency cannabis using adolescents (aged 13-14 years) self-reported symptoms of probable depression, anxiety, and auditory hallucinations.
Of the 6672 participants, high-potency cannabis was used by 2.6 % (n=171) and low-potency by 0.6 % (n=38). After adjustment for sociodemographic factors, tobacco and alcohol use, in comparison to participants who had never used cannabis, people who had used high-potency but not low-potency cannabis were more likely to report symptoms of depression (odds ratio 1.59 [95 % confidence interval 1.06, 2.39), anxiety (OR 1.45, 95 % CI 0.96, 2.20), and auditory hallucinations (OR 1.56, 95 % CI 0.98, 2.47).
High-potency cannabis use is associated with an increased risk of probable mental health disorders. Services and programming to minimise drug harms may need to be adapted to pay more attention to cannabis potency.
在合法和非法市场中，高效力大麻（Δ⁹-四氢大麻酚（THC）含量>10%）越来越容易获得。在成人样本中，高效力大麻与精神健康障碍有关，但尚无研究探讨其与青少年的关联。
一项全人群研究比较了未使用大麻、低效力大麻和高效力大麻的青少年（13 - 14岁）自我报告的可能的抑郁、焦虑和幻听症状。
在6672名参与者中，2.6%（n = 171）使用高效力大麻，0.6%（n = 38）使用低效力大麻。在对社会人口学因素、烟草和酒精使用进行调整后，与从未使用过大麻的参与者相比，使用高效力而非低效力大麻的人更有可能报告抑郁症状（比值比1.59 [95%置信区间1.06, 2.39]）、焦虑症状（比值比1.45, 95%置信区间0.96, 2.20）和幻听症状（比值比1.56, 95%置信区间0.98, 2.47）。
使用高效力大麻与可能的精神健康障碍风险增加有关。可能需要调整旨在减少药物危害的服务和项目，以更加关注大麻效力。
