Andersen Elizabeth H, Nagpal Anisha, Eisenlohr-Moul Tory A, Gordon Jennifer L
Department of Psychiatry, Faculty of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.
Psychoneuroendocrinology. 2024 Sep;167:107095. doi: 10.1016/j.psyneuen.2024.107095. Epub 2024 Jun 6.
Increased sensitivity to ovarian hormone changes is implicated in the etiology of reproductive mood disorders across the female lifespan, including menstrually-related mood disorders, perinatal mood disorders, and perimenopausal depression. Developing a method to accurately quantify sensitivity to endogenous hormone fluctuations may therefore facilitate the prediction and prevention of these mental health conditions. Here, we propose one such method applying a synchrony analysis to compute time-lagged cross-correlations between repeated assessments of endogenous hormone levels and self-reported affect. We apply this method to a dataset containing frequent repeated assessments of affective symptoms and the urinary metabolites of estradiol (E2) and progesterone (P4) in 94 perimenopausal females. These preliminary findings suggest that, with further refinement and validation, the proposed method holds promise as a diagnostic tool to be used in clinical practice and to advance research investigating the etiology of reproductive mood disorders.
对卵巢激素变化的敏感性增加与女性一生中生殖情绪障碍的病因有关，包括与月经相关的情绪障碍、围产期情绪障碍和围绝经期抑郁症。因此，开发一种准确量化对内源性激素波动敏感性的方法可能有助于预测和预防这些心理健康状况。在这里，我们提出了一种这样的方法，应用同步分析来计算内源性激素水平的重复评估与自我报告的情绪之间的时间滞后互相关。我们将此方法应用于一个数据集，该数据集包含对94名围绝经期女性的情感症状以及雌二醇（E2）和孕酮（P4）的尿液代谢物的频繁重复评估。这些初步结果表明，经过进一步完善和验证，所提出的方法有望成为一种用于临床实践的诊断工具，并推动对生殖情绪障碍病因的研究。
