Drewe R H, Hiscott P, Lee W R
Ophthalmologica. 1985;190(3):158-67. doi: 10.1159/000309513.
The clinical, ultrasonographic and histopathological features (including immunohistochemistry and transmission electron microscopy) are described in a solitary astrocytic hamartoma of the retina in a 3-year-old child who was otherwise normal. Focal calcification was detected by ultrasound and this contributed to a misdiagnosis of retinoblastoma. The small tumour was located within the nerve fibre layer at the posterior pole and consisted solely of uniformly distributed astrocytes with benign cytological characteristics. Calcospherites were found within the cytoplasm of the astrocytes. Vascular abnormalities included intimal fibroplasia of arterioles with calcification of the internal elastic lamina and widespread endothelial proliferation; such abnormalities have not been previously noted in tumours with this degree of differentiation. The histological features are compared with those in previous reports of this rare tumour.
本文描述了一名3岁正常儿童视网膜孤立性星形细胞瘤的临床、超声及组织病理学特征（包括免疫组化和透射电子显微镜检查）。超声检查发现局灶性钙化，这导致了视网膜母细胞瘤的误诊。小肿瘤位于后极的神经纤维层内，仅由具有良性细胞学特征的均匀分布的星形细胞组成。在星形细胞的细胞质内发现了钙球。血管异常包括小动脉内膜纤维增生伴内弹力层钙化和广泛的内皮细胞增生；这种异常在以前分化程度如此之高的肿瘤中尚未见报道。本文将该肿瘤的组织学特征与以往关于这种罕见肿瘤的报道进行了比较。
