Endocrinology Department, Northern Lisbon University Center, Lisbon, Portugal.
Endocrinology Department, Northern Lisbon University Center, Lisbon, Portugal; Endocrinology University Clinic, Lisbon Medical School, Lisbon, Portugal.
Endocrinol Diabetes Nutr (Engl Ed). 2024 May;71(5):216-220. doi: 10.1016/j.endien.2024.03.018.
It is suggested to wait at least 3 months to repeat a fine needle aspiration cytology (FNAC) to avoid possible inflammatory cytological changes induced by a previous procedure. This study evaluated the influence of the interval between 2 FNACs in a cohort with a previous non-diagnostic (ND) FNAC. We analysed the occurrence of ND or atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) results in the second FNAC, based on the intervals between procedures.
Retrospective study (2017-2020) including thyroid nodules with a ND result, subjected to another FNAC. Demographic, clinical and echographic data, interval between FNACs and their results were collected. We considered the intervals: ≤/>3 months and ≤/>6 months. Second FNAC results were classified as ND, AUS/FLUS or diagnostic (including the other Bethesda categories).
Included 190 nodules (190 patients - 82.1% women, mean age 60±13.7 years) with a first ND FNAC. The second FNAC results were: ND in 63 cases, AUS/FLUS in 9 and diagnostic in 118 cases. There were no statistical differences in FNAC results performed≤3 months (13 ND, 2 AUS/FLUS, 19 diagnostic) vs >3 months (50 ND, 7 AUS/FLUS, 99 diagnostic; p=0.71). Similarly, there were no statistical differences considering a longer time interval: ≤6 months (32 ND, 3 AUS/FLUS, 59 diagnostic) vs >6 months (31 ND, 6 AUS/FLUS, 59 diagnostic; p=0.61).
Time interval between FNACs was not relevant to the final cytological result. Early FNAC repetition did not increase the cases of ND or AUS/FLUS.
有人建议至少等待 3 个月重复进行细针抽吸细胞学检查（FNAC），以避免先前操作引起的可能的炎症性细胞学变化。本研究评估了在先前非诊断性（ND）FNAC 的队列中两次 FNAC 之间的间隔对其影响。我们根据操作之间的间隔分析了第二次 FNAC 中 ND 或意义未明的非典型性/滤泡性病变意义未明（AUS/FLUS）结果的发生。
回顾性研究（2017-2020 年）包括 ND 结果的甲状腺结节，行另一项 FNAC。收集了人口统计学、临床和超声数据，以及 FNAC 之间的间隔及其结果。我们考虑了以下间隔：≤/＞3 个月和≤/＞6 个月。第二次 FNAC 结果分为 ND、AUS/FLUS 或诊断（包括其他 Bethesda 类别）。
纳入了 190 个结节（190 例患者-82.1%为女性，平均年龄 60±13.7 岁），首次 FNAC 为 ND。第二次 FNAC 结果为：63 例 ND、9 例 AUS/FLUS 和 118 例诊断。在 3 个月内（13 例 ND、2 例 AUS/FLUS、19 例诊断）与 3 个月以上（50 例 ND、7 例 AUS/FLUS、99 例诊断）进行 FNAC 检查的结果无统计学差异（p=0.71）。同样，考虑更长的时间间隔也没有统计学差异：≤6 个月（32 例 ND、3 例 AUS/FLUS、59 例诊断）与＞6 个月（31 例 ND、6 例 AUS/FLUS、59 例诊断）相比（p=0.61）。
FNAC 之间的时间间隔与最终细胞学结果无关。早期重复 FNAC 并未增加 ND 或 AUS/FLUS 病例。
