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肠道异尖线虫病引起的腹水:一例报告及文献复习

Ascites Caused by Intestinal Anisakiasis: A Case Report and Literature Review.

作者信息

Furuta Yutaka, Matsuda Naoto, Wakakuri Hiroaki, Hyodo Hideya, Ohara Toshihiko, Takagi Gen, Yasutake Masahiro

机构信息

Department of Pediatrics, Vanderbilt University Medical Center.

Department of General Medicine and Health Science, Nippon Medical School.

出版信息

J Nippon Med Sch. 2024 Jun 18. doi: 10.1272/jnms.JNMS.2025_92-401.

DOI:10.1272/jnms.JNMS.2025_92-401
PMID:38897944
Abstract

Anisakiasis is a parasitic infection affecting the human gastrointestinal tract. It is caused by the consumption of contaminated, raw or inadequately cooked fish or squid, which is typically used for making sushi and sashimi. Most cases involve gastric anisakiasis, whereas intestinal anisakiasis is rare. This report describes the case of a 63-year-old Japanese woman with a history of raw fish consumption who presented with acute-onset abdominal pain and vomiting. Abdominal computed tomography (CT) demonstrated thickened small bowel loops and ascites on the liver surface. The patient was admitted for supportive care. On the second day of hospitalization, contrast-enhanced abdominal CT revealed that the ascites had moved from the liver surface to the pouch of Douglas. On the fifth day of hospitalization, the patient was discharged with a substantial improvement in abdominal pain. Five days after the discharge, her eosinophil count was elevated, and parasitic disease was therefore suspected. Anti-Anisakis IgG/A and IgE (RAST) antibody levels were elevated, confirming the diagnosis of intestinal anisakiasis. A review of 51 reported cases of intestinal anisakiasis suggests that the presence of ascites and measurement of anti-Anisakis antibody titers are helpful for diagnosis in cases presenting with nonspecific abdominal symptoms after consumption of raw or undercooked fish.

摘要

异尖线虫病是一种影响人类胃肠道的寄生虫感染。它是由于食用了受污染的生鱼或未煮熟的鱼或鱿鱼引起的,这些食物通常用于制作寿司和生鱼片。大多数病例为胃异尖线虫病,而肠异尖线虫病较为罕见。本报告描述了一名63岁有食用生鱼史的日本女性,她出现急性腹痛和呕吐。腹部计算机断层扫描(CT)显示小肠袢增厚以及肝表面有腹水。患者入院接受支持治疗。住院第二天,增强腹部CT显示腹水已从肝表面转移至Douglas陷凹。住院第五天,患者出院,腹痛有显著改善。出院五天后,她的嗜酸性粒细胞计数升高,因此怀疑患有寄生虫病。抗异尖线虫IgG/A和IgE(RAST)抗体水平升高,确诊为肠异尖线虫病。对51例报告的肠异尖线虫病病例的回顾表明,腹水的存在以及抗异尖线虫抗体滴度的测定有助于诊断食用生鱼或未煮熟的鱼后出现非特异性腹部症状的病例。

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