The Research Center of National Drug Policy & Ecosystem, China Pharmaceutical University, No. 639 Longmian Avenue, Jiangning District, Nanjing City, Jiangsu Province, China.
School of Public Health, Fudan University, No. 130 Dongan Road, Shanghai, China.
Sci Rep. 2024 Jun 19;14(1):14129. doi: 10.1038/s41598-024-64772-4.
To assess the health utility value (HUV) of Rheumatoid Arthritis (RA) patients and its influencing factors in China. A cross-sectional survey was conducted in 8 tertiary hospitals across four capital-cities. The demographic characteristics, patient-reported outcomes including the HUV got by EQ-5D-5L, clinical characteristics, and clinician-reported outcomes of 171 RA patients were collected both from themselves and their physicians. Both the univariate and multivariate analyses were used to assess the potential factors of EQ-5D-5L HUV of the patients. The mean age of the patients was 50.7 years, with female being 64.9% (n = 111). The mean HUV and EQ visual analogue scale score of all patients were 0.586 and 47.3, respectively. The univariate analysis showed that the patients who were female, older, living in rural areas, with lower education level, advanced disease stage, higher the patient's assessment of arthritis pain visual analogue scale (PtAAP-VAS), the patient's global assessment of disease activity visual analogue scale (PtGADA-VAS), and the Physician's global assessment of disease activity visual analogue scale (PhGADA-VAS) scores had significantly lower EQ-5D-5L HUVs. The multivariate analysis further suggested that older age, female, higher body mass index and higher PtGADA-VAS score were statistically significantly related to lower HUVs. The study provided the HUVs for RA patients with different characteristics and outcomes, which could be used in the economic evaluation of interventions for the RA patients. The identified factors could also assist the health care managing and improving the health-related quality of life on RA patients.
评估中国类风湿关节炎（RA）患者的健康效用值（HUV）及其影响因素。在四个省会城市的 8 家三级医院进行了横断面调查。收集了 171 名 RA 患者的人口统计学特征、患者报告的结局（包括 EQ-5D-5L 获得的 HUV）、临床特征以及医生报告的结局。使用单因素和多因素分析来评估患者 EQ-5D-5L HUV 的潜在因素。患者的平均年龄为 50.7 岁，女性占 64.9%（n=111）。所有患者的平均 HUV 和 EQ 视觉模拟量表评分分别为 0.586 和 47.3。单因素分析显示，女性、年龄较大、居住在农村地区、受教育程度较低、疾病分期较晚、关节炎疼痛视觉模拟量表（PtAAP-VAS）患者评估得分、疾病活动视觉模拟量表（PtGADA-VAS）和医生疾病活动视觉模拟量表（PhGADA-VAS）评分较高的患者，EQ-5D-5L HUV 明显较低。多因素分析进一步表明，年龄较大、女性、较高的体重指数和较高的 PtGADA-VAS 评分与较低的 HUV 显著相关。本研究为具有不同特征和结局的 RA 患者提供了 HUV，可用于 RA 患者干预措施的经济评估。确定的因素还可以帮助医疗保健管理并改善 RA 患者的健康相关生活质量。
