Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
School of Pharmaceutical Science and Technology, Tianjin University, Room 209, 24th Building, 92th Weijin Road, Nankai District, Tianjin, 300072, China.
Health Qual Life Outcomes. 2022 Jun 16;20(1):96. doi: 10.1186/s12955-022-02003-y.
SF-6Dv2, the latest version of SF-6D, has been developed recently, and its measurement properties remain to be evaluated and compared with the EQ-5D-5L. The aim of this study was to assess and compare the measurement properties of the SF-6Dv2 and the EQ-5D-5L in a large-sample health survey among the Chinese population.
Data were obtained from the 2020 Health Service Survey in Tianjin, China. Respondents were randomly selected and invited to complete both the EQ-5D-5L and SF-6Dv2 through face-to-face interviews or self-administration. Health utility values were calculated by the Chinese value sets for the two measures. Ceiling and floor effects were firstly evaluated. Convergent validity and discriminate validity were examined using Spearman's rank correlation and effect sizes, respectively. The agreement was assessed using intraclass correlation coefficients (ICC). Sensitivity was compared using relative efficiency and receiver operating characteristic.
Among 19,177 respondents (49.3% male, mean age 55.2 years, ranged 18-102 years) included in this study, the mean utility was 0.939 (0.168) for EQ-5D-5L and 0.872 (0.184) for SF-6Dv2. A higher ceiling effect was observed in EQ-5D-5L than in SF-6Dv2 (72.8% vs. 36.1%). The Spearman's rank correlation (range: 0.30-0.69) indicated an acceptable convergent validity between the dimensions of EQ-5D-5L and SF-6Dv2. The SF-6Dv2 showed slightly better discriminative capacities than the EQ-5D-5L (ES: 0.126-2.675 vs. 0.061-2.256). The ICC between the EQ-5D-5L and SF-6Dv2 utility values of the total sample was 0.780 (p < 0.05). The SF-6Dv2 had 29.0-179.2% higher efficiency than the EQ-5D-5L at distinguishing between respondents with different external health indicators, while the EQ-5D-5L was found to be 8.2% more efficient at detecting differences in self-reported health status than the SF-6Dv2.
Both the SF-6Dv2 and EQ-5D-5L have been demonstrated to be comparably valid and sensitive when used in Chinese population health surveys. The two measures may not be interchangeable given the moderate ICC and the systematic difference in utility values between the SF-6Dv2 and EQ-5D-5L. Further research is warranted to compare the test-retest reliability and responsiveness.
SF-6Dv2 是 SF-6D 的最新版本，最近已经开发出来，其测量特性仍有待评估和与 EQ-5D-5L 进行比较。本研究的目的是评估和比较 SF-6Dv2 和 EQ-5D-5L 在中国人群大型健康调查中的测量特性。
数据来自中国天津 2020 年卫生服务调查。通过面对面访谈或自我管理，随机选择受访者并邀请他们完成 EQ-5D-5L 和 SF-6Dv2。使用两种措施的中国价值集计算健康效用值。首先评估上限和下限效应。使用 Spearman 秩相关和效应大小分别检验收敛有效性和区分有效性。使用组内相关系数（ICC）评估一致性。使用相对效率和接收者操作特征比较敏感性。
在这项研究中，纳入了 19177 名受访者（49.3%为男性，平均年龄 55.2 岁，年龄范围为 18-102 岁），EQ-5D-5L 的平均效用为 0.939（0.168），SF-6Dv2 的平均效用为 0.872（0.184）。EQ-5D-5L 观察到更高的上限效应（72.8%比 36.1%）。EQ-5D-5L 和 SF-6Dv2 维度之间的 Spearman 秩相关（范围：0.30-0.69）表明收敛有效性可接受。SF-6Dv2 比 EQ-5D-5L 显示出稍好的区分能力（ES：0.126-2.675 比 0.061-2.256）。总样本中 EQ-5D-5L 和 SF-6Dv2 效用值之间的 ICC 为 0.780（p<0.05）。SF-6Dv2 在区分不同外部健康指标的受访者方面比 EQ-5D-5L 效率高 29.0-179.2%，而 EQ-5D-5L 在检测自我报告健康状况差异方面比 SF-6Dv2 效率高 8.2%。
当在中国人群健康调查中使用时，SF-6Dv2 和 EQ-5D-5L 均被证明具有可比性和敏感性。鉴于 SF-6Dv2 和 EQ-5D-5L 之间的 ICC 中等且效用值存在系统差异，这两种措施可能无法互换。需要进一步研究比较测试-重测可靠性和反应性。
