“非编码”链会编码吗？

Does the 'non-coding' strand code?

作者信息

Sharp P M

出版信息

Nucleic Acids Res. 1985 Feb 25;13(4):1389-97. doi: 10.1093/nar/13.4.1389.

DOI:10.1093/nar/13.4.1389

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC341079/

Abstract

The hypothesis that DNA strands complementary to the coding strand contain in phase coding sequences has been investigated. Statistical analysis of the 50 genes of bacteriophage T7 shows no significant correlation between patterns of codon usage on the coding and non-coding strands. In Bacillus and yeast genes the correlation observed is not different from that expected with random synonymous codon usage, while a high correlation seen in 52 E. coli genes can be explained in terms of an excess of RNY codons. A deficiency of UUA, CUA and UCA codons (complementary to termination) seems to be restricted to the E. coli genes, and may be due to low abundance of the relevant cognate tRNA species. Thus the analysis shows that the non-coding strand has the properties expected of a sequence complementary to a coding strand, with no indications that it encodes, or may have encoded, proteins.

摘要

与编码链互补的DNA链包含同相编码序列这一假说已得到研究。对噬菌体T7的50个基因进行的统计分析表明，编码链和非编码链上密码子使用模式之间没有显著相关性。在芽孢杆菌和酵母基因中观察到的相关性与随机同义密码子使用所预期的相关性没有差异，而在52个大肠杆菌基因中看到的高相关性可以用RNY密码子过量来解释。UUA、CUA和UCA密码子（与终止密码子互补）的缺乏似乎仅限于大肠杆菌基因，这可能是由于相关同源tRNA种类的丰度较低。因此，分析表明非编码链具有与编码链互补序列所预期的特性，没有迹象表明它编码或可能曾经编码过蛋白质。

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Codon catalog usage is a genome strategy modulated for gene expressivity.密码子编目使用是一种为基因表达性而调节的基因组策略。

Nucleic Acids Res. 1981 Jan 10;9(1):r43-74. doi: 10.1093/nar/9.1.213-b.

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Expected frequencies of codon use as a function of mutation rates and codon fitnesses.作为突变率和密码子适应性函数的密码子使用预期频率。

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