密码子编目使用是一种为基因表达性而调节的基因组策略。
Codon catalog usage is a genome strategy modulated for gene expressivity.
作者信息
Grantham R, Gautier C, Gouy M, Jacobzone M, Mercier R
出版信息
Nucleic Acids Res. 1981 Jan 10;9(1):r43-74. doi: 10.1093/nar/9.1.213-b.
Abstract
The nucleic acid sequence bank now contains 161 mRNAs, 43 new genes are added. One sequence, that of B. mori fibroin, is dropped due to uncertainty on the starting point for translation. Frequencies of all codons are given for each gene added and for each genome type in the total bank. A new series of correspondence analyses on codon use is presented, substantiating the genome hypothesis. Internal regulation of mRNA expression by different third base choices between quartet and duet codons is proposed for bacterial genes.
摘要
核酸序列库目前包含161种信使核糖核酸（mRNA），新增了43个新基因。由于翻译起始点存在不确定性，家蚕纤维蛋白的一个序列被剔除。给出了添加的每个基因以及整个文库中每种基因组类型的所有密码子频率。提出了关于密码子使用的一系列新的对应分析，证实了基因组假说。对于细菌基因，提出了通过四重密码子和二重密码子之间不同的第三位碱基选择对信使核糖核酸表达进行内部调控。
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