Newly Identified Gene Variants Put the "Excite"-ment Back in Kv1.3 Channelopathy.
作者信息
Glasscock Edward
机构信息
Department of Biological Sciences, Southern Methodist University.
出版信息
Epilepsy Curr. 2024 Mar 1;24(3):200-202. doi: 10.1177/15357597241234244. eCollection 2024 May-Jun.
Abstract
摘要
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本文引用的文献
1
De novo variants in KCNA3 cause developmental and epileptic encephalopathy.KCNA3基因的新生变异导致发育性和癫痫性脑病。
Ann Neurol. 2024 Feb;95(2):365-376. doi: 10.1002/ana.26826. Epub 2023 Dec 28.
2
Novel Genetic Variants Expand the Functional, Molecular, and Pathological Diversity of Channelopathy.新型遗传变异扩大了通道病的功能、分子和病理多样性。
Int J Mol Sci. 2023 May 16;24(10):8826. doi: 10.3390/ijms24108826.
3
Blockade of Kv1.3 Potassium Channel Inhibits Microglia-Mediated Neuroinflammation in Epilepsy.阻断 Kv1.3 钾通道抑制癫痫中的小胶质细胞介导的神经炎症。
Int J Mol Sci. 2022 Nov 24;23(23):14693. doi: 10.3390/ijms232314693.
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Kv1.3 K Channel Physiology Assessed by Genetic and Pharmacological Modulation.Kv1.3 钾通道的生理机能可通过遗传和药理学调节进行评估。
Physiology (Bethesda). 2023 Jan 1;38(1):0. doi: 10.1152/physiol.00010.2022. Epub 2022 Aug 23.
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Developmental and epileptic encephalopathies: from genetic heterogeneity to phenotypic continuum.发育性和癫痫性脑病：从遗传异质性到表型连续统。
Physiol Rev. 2023 Jan 1;103(1):433-513. doi: 10.1152/physrev.00063.2021. Epub 2022 Aug 11.
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Kv1.3 Channel as a Key Therapeutic Target for Neuroinflammatory Diseases: State of the Art and Beyond.Kv1.3通道作为神经炎症性疾病的关键治疗靶点：现状与展望
Front Neurosci. 2020 Jan 14;13:1393. doi: 10.3389/fnins.2019.01393. eCollection 2019.
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