The Benefits of "Spoilt Milk": Lactic Acid Can Limit Excitability via HCAR1.
作者信息
Borges Karin
机构信息
Department of Pharmacology, The University of Queensland.
出版信息
Epilepsy Curr. 2024 Apr 30;24(3):206-208. doi: 10.1177/15357597241249037. eCollection 2024 May-Jun.
Abstract
摘要
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本文引用的文献
1
Glycolytic lactate production supports status epilepticus in experimental animals.糖酵解产生的乳酸支持实验动物的癫痫持续状态。
Ann Clin Transl Neurol. 2023 Oct;10(10):1873-1884. doi: 10.1002/acn3.51881. Epub 2023 Aug 25.
2
Glycolysis regulates neuronal excitability via lactate receptor, HCA1R.糖酵解通过乳酸受体 HCA1R 调节神经元兴奋性。
Brain. 2023 May 2;146(5):1888-1902. doi: 10.1093/brain/awac419.
3
Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue.激活乳酸受体 HCAR1 可下调啮齿动物和人脑组织中的神经元活性。
J Cereb Blood Flow Metab. 2022 Sep;42(9):1650-1665. doi: 10.1177/0271678X221080324. Epub 2022 Mar 3.
4
The Lactate Receptor HCAR1 Modulates Neuronal Network Activity through the Activation of G and G Subunits.乳酸受体 HCAR1 通过激活 G 和 G 亚基调节神经元网络活动。
J Neurosci. 2019 Jun 5;39(23):4422-4433. doi: 10.1523/JNEUROSCI.2092-18.2019. Epub 2019 Mar 29.
5
Neurons rely on glucose rather than astrocytic lactate during stimulation.神经元在受到刺激时依赖于葡萄糖而不是星形胶质细胞中的乳酸。
J Neurosci Res. 2019 Aug;97(8):883-889. doi: 10.1002/jnr.24374. Epub 2018 Dec 21.
6
Brain Glucose Metabolism: Integration of Energetics with Function.脑葡萄糖代谢：能量与功能的整合。
Physiol Rev. 2019 Jan 1;99(1):949-1045. doi: 10.1152/physrev.00062.2017.
7
Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1.运动通过乳酸受体 HCAR1 诱导脑内 VEGF 和血管生成。
Nat Commun. 2017 May 23;8:15557. doi: 10.1038/ncomms15557.
8
A probable dual mode of action for both L- and D-lactate neuroprotection in cerebral ischemia.L-乳酸和D-乳酸在脑缺血中神经保护的一种可能的双重作用模式。
J Cereb Blood Flow Metab. 2015 Oct;35(10):1561-9. doi: 10.1038/jcbfm.2015.115. Epub 2015 Jun 3.
9
Lactate receptor sites link neurotransmission, neurovascular coupling, and brain energy metabolism.乳酸受体位点连接神经传递、神经血管耦合和脑能量代谢。
Cereb Cortex. 2014 Oct;24(10):2784-95. doi: 10.1093/cercor/bht136. Epub 2013 May 21.
10
Is lactate a volume transmitter of metabolic states of the brain?乳酸是大脑代谢状态的容量传递物质吗？
Front Neuroenergetics. 2012 Mar 19;4:5. doi: 10.3389/fnene.2012.00005. eCollection 2012.
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