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酷似动静脉畸形的小脑血管母细胞瘤:一例报告

Cerebellar Hemangioblastoma Mimicking Arteriovenous Malformation: A Case Report.

作者信息

Al-Mutairi Abdullah A, AlHifzi Abdulkhaliq, Alghoraiby Rinad, Faden Talal

机构信息

Diagnostic Radiology, Prince Sultan Military Medical City, Riyadh, SAU.

Diagnostic Radiology, King Khalid University Hospital, Riyadh, SAU.

出版信息

Cureus. 2024 May 20;16(5):e60671. doi: 10.7759/cureus.60671. eCollection 2024 May.

DOI:10.7759/cureus.60671
PMID:38899263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11186394/
Abstract

Hemangioblastoma (HBM) is a tumor distinguished by the presence of stromal cells and small vessels. These stromal cells represent stem cells, which, due to the influence of the neoplasm, proliferate and differentiate into "vasoformative elements" that create new blood vessels. Hemangioblastomas resemble arteriovenous malformation (AVM) in imaging features, characterized by an apparent vascular blush, the presence of multiple feeding vessels, and evident draining veins observed on digital subtraction angiography (DSA). Our study presents a case of HBM in the right cerebellar hemisphere mimicking AVM. The patient had been diagnosed with AVM in the same location two years ago and managed with endovascular embolization. One month prior, the patient experienced severe headaches, imbalance, nausea, left ear fullness, blurry vision, and high blood pressure. The imaging feature suggests HBM rather than AVM. The patient next underwent sub-occipital craniotomy and tumor resection with external ventricular drainage (EVD) insertion. The histopathological report of the excised mass confirmed HBM. In conclusion, AVM and HBM rarely occur together. Recent research indicates that HBM and AVM have exact embryologic origins and need later genetic alterations to develop into symptomatic lesions. Further research is required to clarify the uncommon combination of these lesions.

摘要

血管母细胞瘤(HBM)是一种以基质细胞和小血管为特征的肿瘤。这些基质细胞代表干细胞,由于肿瘤的影响,它们会增殖并分化为形成血管的成分,从而形成新的血管。血管母细胞瘤在影像学特征上类似于动静脉畸形(AVM),其特征是在数字减影血管造影(DSA)上表现为明显的血管造影剂充盈、存在多条供血血管以及明显的引流静脉。我们的研究报告了一例位于右小脑半球的模仿AVM的HBM病例。该患者两年前曾被诊断为同一部位的AVM,并接受了血管内栓塞治疗。一个月前,患者出现严重头痛、平衡失调、恶心、左耳胀满、视力模糊和高血压。影像学特征提示为HBM而非AVM。该患者随后接受了枕下开颅手术并切除肿瘤,同时插入了脑室外引流(EVD)。切除肿块的组织病理学报告证实为HBM。总之,AVM和HBM很少同时发生。最近的研究表明,HBM和AVM有确切的胚胎学起源,需要后期的基因改变才能发展为有症状的病变。需要进一步的研究来阐明这些病变的罕见组合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2314/11186394/641d590a1ebe/cureus-0016-00000060671-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2314/11186394/7c32b8b85fac/cureus-0016-00000060671-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2314/11186394/620ac58d3b15/cureus-0016-00000060671-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2314/11186394/641d590a1ebe/cureus-0016-00000060671-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2314/11186394/7c32b8b85fac/cureus-0016-00000060671-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2314/11186394/620ac58d3b15/cureus-0016-00000060671-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2314/11186394/641d590a1ebe/cureus-0016-00000060671-i03.jpg

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Medicine (Baltimore). 2024 Feb 9;103(6):e37162. doi: 10.1097/MD.0000000000037162.
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Case Report of a Hemangioblastoma With Large Blood Vessels and Rare Vascular Anomalies: Is It Fibromuscular Dysplasia or Arteriovenous Malformation Association?一例伴有大血管及罕见血管异常的血管母细胞瘤病例报告:是纤维肌发育异常还是动静脉畸形伴发?
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Central nervous system vascular malformations: A clinical review.
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