Kuylenstierna J, Karlberg B E, Morales O
Prostaglandins Leukot Med. 1985 Apr;18(1):19-30. doi: 10.1016/0262-1746(85)90046-0.
We studied renal vein concentrations of prostaglandin E2 (PGE2) and activity of the renin-angiotensin system in 9 normotensive young men (NT), 17 hypertensive patients with unilateral renal artery stenosis (URS), and 26 patients with essential hypertension (EH) of whom 12 had low renin essential hypertension (LRH). The PGE2 concentration, plasma renin activity (PRA), and angiotensin II (A II) were measured in the inferior vena cava and were compared with the mean concentration for both renal veins under basal conditions and without pharmacological interference. The renal vein PGE2 concentrations were higher in NT (p less than 0.01) and URS (p less than 0.05) than in LRH. However, there were no significant differences in A II concentrations between the groups, nor were there any correlations to PGE2 concentrations. The positive correlation between PRA and PGE2 (r = 0.29, p less than 0.02) indicates that PGE2 may contribute to the activation of the renin-angiotensin system or that there may be a common mechanism for stimulation of both hormonal systems. Our results are not compatible with the hypothesis that a reduction of PGE2 production is a specific feature of patients with EH.
我们研究了9名血压正常的年轻男性（NT）、17名单侧肾动脉狭窄（URS）的高血压患者以及26名原发性高血压（EH）患者（其中12名为低肾素原发性高血压患者（LRH））的肾静脉前列腺素E2（PGE2）浓度和肾素-血管紧张素系统活性。在基础条件下且无药物干预的情况下，测量下腔静脉中的PGE2浓度、血浆肾素活性（PRA）和血管紧张素II（A II），并将其与双侧肾静脉的平均浓度进行比较。NT组（p<0.01）和URS组（p<0.05）的肾静脉PGE2浓度高于LRH组。然而，各组之间A II浓度无显著差异，且与PGE2浓度也无相关性。PRA与PGE2之间的正相关（r = 0.29，p<0.02）表明，PGE2可能有助于肾素-血管紧张素系统的激活，或者可能存在刺激这两种激素系统的共同机制。我们的结果与“PGE2生成减少是EH患者的一个特定特征”这一假设不相符。
