Ruilope L, Garcia Robles R, Barrientos A, Bernis C, Alcazar J, Tresguerres J A, Mancheño E, Millet V G, Sancho J, Rodicio J L
Clin Exp Hypertens A. 1982;4(6):989-1000. doi: 10.3109/10641968209060767.
In a group of 26 patients diagnosed as essential hypertensive (EH) and in a control group (CG) of 27 normotensive volunteers the urinary excretion of PGE2, plasma renin activity (PRA) and plasma aldosterone were measured. EH patients were classified into normoreninemic (NREH) (n = 21) and hyporeninemic (LREH) (n = 5) by the response of PRA to the combined stimuli of ambulation and furosemide. Urinary PGE2 excretion was higher in NREH than in CG (p less than 0.05) while LREH showed values lower than in CG (p less than 0.001). Plasma aldosterone levels were similar in the three groups. In CG and EH patients PRA and urinary PGE2 were closely related (CG r = 0.516, p less than 0.05, EH patients r = 0.674, p less than 0.001). Indomethacin administration induced a decrease of PGE2 in both CG (n = 8) and NREH (n = 8) (p less than 0.01). In contrast, indomethacin induced no changes in PGE2 excretion of LREH (n = 5). Furthermore in the group of patients with NREH indomethacin induced a significant increase in blood pressure (p less than 0.01) and body weight (p less than 0.01) while glomerular filtration rate, 24 hour natriuresis PRA and plasma aldosterone decreased (p less than 0.01). On the contrary, in LREH indomethacin did not alter any of the parameters measured. These results indicate that LREH and NREH may be regarded as two different populations distinguishable not only by different secretion of PRA but also by different excretion of PGE2 in urine and by their characteristic response to indomethacin.
对26例诊断为原发性高血压（EH）的患者及27名血压正常的志愿者组成的对照组（CG），测定了尿中前列腺素E2（PGE2）的排泄量、血浆肾素活性（PRA）和血浆醛固酮水平。根据PRA对步行和速尿联合刺激的反应，将EH患者分为正常肾素型（NREH）（n = 21）和低肾素型（LREH）（n = 5）。NREH患者尿中PGE2排泄量高于CG（p < 0.05），而LREH患者的值低于CG（p < 0.001）。三组患者的血浆醛固酮水平相似。在CG和EH患者中，PRA与尿中PGE2密切相关（CG中r = 0.516，p < 0.05；EH患者中r = 0.674，p < 0.001）。给予消炎痛后，CG组（n = 8）和NREH组（n = 8）的PGE2均降低（p < 0.01）。相反，消炎痛对LREH组（n = 5）的PGE2排泄无影响。此外，在NREH患者组中，消炎痛使血压显著升高（p < 0.01）、体重增加（p < ！0.01），而肾小球滤过率、24小时尿钠排泄量、PRA和血浆醛固酮均降低（p < 0.01）。相反，消炎痛对LREH组所测的任何参数均无改变。这些结果表明，LREH和NREH可能被视为两个不同的群体，不仅可通过PRA的不同分泌来区分，还可通过尿中PGE2的不同排泄以及它们对消炎痛的特征性反应来区分。
