Rethinam Senthil
Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamilnadu, India.
Nat Prod Res. 2024 Jun 20:1-3. doi: 10.1080/14786419.2024.2368757.
Fibrin is limited by some factors that limit its clinical applicability, such as rapid degradation, poor water solubility, and low oral bioavailability. However, they can be applied clinically when they are included in the development of biocompatible fibrin nanoparticles (F-NPs). In this present study, F-NPs were prepared using co-precipitation techniques and In vitro studies using oral cancer cell lines also proved the anticancer activity of F-NPs. The study devised a technology for converting slaughterhouse waste into a value-added material such as anti-cancer F-NPs.
纤维蛋白受到一些限制其临床应用的因素影响，如快速降解、水溶性差和口服生物利用度低。然而，当它们被纳入生物相容性纤维蛋白纳米颗粒（F-NPs）的研发中时，就可以应用于临床。在本研究中，采用共沉淀技术制备了F-NPs，使用口腔癌细胞系进行的体外研究也证明了F-NPs的抗癌活性。该研究设计了一种将屠宰场废物转化为增值材料（如抗癌F-NPs）的技术。
