Marruganti Crystal, Romandini Mario, Gaeta Carlo, Trovato Emanuele, Cinotti Elisa, Rubegni Pietro, D'Aiuto Francesco, Grandini Simone
Unit of Periodontology, Endodontology and Restorative Dentistry, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Unit of Periodontology, UCL Eastman Dental Institute, London, UK.
J Periodontal Res. 2025 Feb;60(2):134-143. doi: 10.1111/jre.13314. Epub 2024 Jun 20.
To assess the impact of non-surgical periodontitis treatment over conventional dermatological treatment on the severity and extent of psoriasis in patients affected by comorbid psoriasis and periodontitis.
Seventy-four patients affected by both psoriasis and Stages I-IV periodontitis were randomized to receive either Steps 1-2 (non-surgical) of periodontal therapy (test group; n = 37) or no treatment (control group; n = 37). The two groups were balanced in terms of psoriasis medications, with the majority of the included patients undergoing biologics (74.0%) as monotherapy, while minor proportions were under systemic medications (13.7%) or none/topical/phototherapy (12.3%). The psoriasis area severity index (PASI) was regarded as the primary outcome. The Body Surface Area (BSA) and the Dermatology Life Quality Index (DLQI) were additionally considered as dermatological outcomes. Probing pocket depth, recession depth, clinical attachment level, periodontal inflamed surface area, and full-mouth plaque and bleeding scores were also measured. [Correction added on July 5, 2024, after first online publication: The preceding sentence has been revised].
Periodontal therapy in the test group led to statistically significant lower PASI scores at 10 weeks (mean = 3.15; standard deviation [SD] = 3.78) compared to the control group (mean = 7.11; SD = 6.09) (mean difference [MD] = -4.0; 95% confidence interval [CI]: -6.3, -1.6; p = .001). The test group also showed improvements in BSA (MD = -4.3) and periodontal parameters compared to the control group. DLQI only showed a non-statistically significant tendency (MD = -2.0).
Steps 1-2 of periodontal therapy showed an additional effect over conventional dermatological treatment in reducing the severity and extent of psoriasis (Clinicaltrials.gov: NCT05311501).
评估非手术性牙周炎治疗相对于传统皮肤科治疗对合并银屑病和牙周炎患者银屑病严重程度及范围的影响。
74例同时患有银屑病和I-IV期牙周炎的患者被随机分为两组，分别接受牙周治疗的第1-2步（非手术治疗）（试验组；n = 37）或不接受治疗（对照组；n = 37）。两组在银屑病用药方面保持平衡，纳入的患者中大多数（74.0%）接受生物制剂作为单一疗法，少数患者接受全身用药（13.7%）或未接受治疗/局部用药/光疗（12.3%）。银屑病面积严重程度指数（PASI）被视为主要结局指标。此外，体表面积（BSA）和皮肤病生活质量指数（DLQI）被视为皮肤科结局指标。还测量了探诊深度、退缩深度、临床附着水平、牙周炎症表面积以及全口菌斑和出血评分。[2024年7月5日首次在线发表后添加的更正：前一句已修订]
与对照组（均值 = 7.11；标准差[SD] = 6.09）相比，试验组在10周时的牙周治疗导致PASI评分在统计学上显著降低（均值 = 3.15；SD = 3.78）（均值差异[MD] = -4.0；95%置信区间[CI]：-6.3，-1.6；p = 0.001）。与对照组相比，试验组在BSA（MD = -4.3）和牙周参数方面也有改善。DLQI仅显示出无统计学意义的趋势（MD = -2.0）。
牙周治疗的第1-2步在减轻银屑病的严重程度和范围方面显示出相对于传统皮肤科治疗的额外效果（Clinicaltrials.gov：NCT05311501）。
