Marruganti Crystal, Malvicini Giulia, Cinotti Elisa, Fuso Aurora, Trovato Emanuele, Rubegni Pietro, Grandini Simone, Gaeta Carlo
Unit of Endodontics and Restorative Dentistry, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Unit of Dermatology, Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
Int Endod J. 2025 Jun;58(6):848-861. doi: 10.1111/iej.14222. Epub 2025 Mar 19.
To evaluate the prevalence of apical periodontitis (AP) and caries in subjects with psoriasis vulgaris.
In total, 152 patients with psoriasis vulgaris were included in the study. The severity and extent of psoriasis were assessed according to the Psoriasis Area Severity Index (PASI), the Body Surface Area (BSA) and the Physician's Global Assessment Scale (PGA). Periapical status was assessed through dental examination and periapical radiographs. Data regarding the Periapical Index (PAI), caries experience expressed as the Decayed, Missing, Filled Teeth Index (DMFT) and psoriasis medications were recorded. A predictive logistic regression model for the presence of AP and a linear regression model were then built to relate the severity and extent of AP to the type of drug therapy taken for psoriasis and to the severity and extent of the skin disease.
Subjects with severe/moderate psoriasis showed a significantly higher prevalence of AP (p = .002) and a higher PAI score (p = .0035) than subjects with mild psoriasis. No significant correlation was found between AP and caries experience (p = .76). The logistic regression model showed that moderate/severe psoriasis increased the odds of having AP [odds ratio (OR) = 1.30 ± 1.088, 1.55]. A negative linear relationship between biological drug intake and PAI score value was observed (coefficient = -.54; p = .04).
The degree of severity of psoriasis is significantly associated with AP, suggesting that psoriasis may play a role in the pathogenesis of AP. However, no significant correlation was observed for caries experience. Furthermore, the immune-modulating drugs taken by these patients did not seem to have different effects on the prevalence of AP.
评估寻常型银屑病患者根尖周炎（AP）和龋齿的患病率。
本研究共纳入152例寻常型银屑病患者。根据银屑病面积严重程度指数（PASI）、体表面积（BSA）和医生整体评估量表（PGA）评估银屑病的严重程度和范围。通过口腔检查和根尖片评估根尖周状况。记录根尖指数（PAI）、以龋失补牙指数（DMFT）表示的龋齿经历以及银屑病用药数据。然后建立AP存在情况的预测逻辑回归模型和线性回归模型，以将AP的严重程度和范围与用于治疗银屑病的药物治疗类型以及皮肤病的严重程度和范围相关联。
与轻度银屑病患者相比，中重度银屑病患者的AP患病率显著更高（p = 0.002），PAI评分更高（p = 0.0035）。未发现AP与龋齿经历之间存在显著相关性（p = 0.76）。逻辑回归模型显示，中重度银屑病增加了患AP的几率[优势比（OR）= 1.30±1.088，1.55]。观察到生物药物摄入量与PAI评分值之间呈负线性关系（系数 = -0.54；p = 0.04）。
银屑病的严重程度与AP显著相关，表明银屑病可能在AP的发病机制中起作用。然而，未观察到与龋齿经历有显著相关性。此外，这些患者服用的免疫调节药物似乎对AP的患病率没有不同影响。
