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无支架输尿管-肠吻合术与机器人辅助根治性膀胱切除术和回肠导管术后输尿管-肠吻合狭窄的关系

Is Stent-Free Ureteroenteric Anastomosis Associated With Lower Ureteroenteric Strictures After Robot-Assisted Radical Cystectomy and Ileal Conduit?

机构信息

Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, New York.

出版信息

Urol Pract. 2024 Jul;11(4):753-759. doi: 10.1097/UPJ.0000000000000597. Epub 2024 May 9.

Abstract

INTRODUCTION

We aimed to investigate the differences in perioperative outcomes, especially ureteroenteric strictures, between patients who underwent a stented ureteroenteric anastomosis at the time of robot-assisted radical cystectomy (RARC) and ileal conduit vs those who did not.

METHODS

A retrospective review of our RARC database was performed (2009-2023). Patients were divided into those who received stented ureteroenteric anastomosis vs those who did not. Propensity score matching was performed in the ratio of 3 (stented ureteroenteric anastomosis) to 1 (stent-free) in terms of age, gender, BMI, race, American Society of Anesthesiologists score, neoadjuvant chemotherapy, Charlson Comorbidity Index, prior radiation therapy, previous abdominal surgery history, clinical T3/clinical T4 stage, preoperative metastasis, and preoperative hydronephrosis. A cumulative incidence curve was used to depict ureteroenteric strictures and a Cox regression model was used to identify variables associated with ureteroenteric strictures.

RESULTS

Four hundred eighty-eight patients underwent RARC, 366 individuals underwent a stented ureteroenteric anastomosis, and 122 patients underwent a stent-free approach. There was no significant difference in 90-day overall complications, high-grade complications, readmissions, UTIs, leakage, and ileus ( > .05). Ureteroenteric strictures occurred at a rate of 13% and 18% at 1 and 2 years, respectively in the stented group, vs 7% and 10% in the stent-free group ( = .05). Stent placement was significantly associated with ureteroenteric strictures.

CONCLUSIONS

Stent-free ureteroenteric anastomosis was associated with fewer strictures following RARC and ileal conduit.

摘要

简介

我们旨在研究接受机器人辅助根治性膀胱切除术(RARC)和回肠导管时行支架置入的输尿管-肠吻合术与未行支架置入的患者围手术期结局的差异,尤其是输尿管肠吻合口狭窄。

方法

对我们的 RARC 数据库进行了回顾性分析(2009-2023 年)。患者分为接受支架置入的输尿管-肠吻合术组和未接受支架置入的输尿管-肠吻合术组。根据年龄、性别、BMI、种族、美国麻醉医师协会评分、新辅助化疗、Charlson 合并症指数、既往放疗、既往腹部手术史、临床 T3/临床 T4 期、术前转移和术前肾积水等因素,采用 3:1 的比例进行倾向评分匹配。采用累积发病率曲线描述输尿管-肠吻合口狭窄情况,采用 Cox 回归模型确定与输尿管-肠吻合口狭窄相关的变量。

结果

488 例患者接受了 RARC,366 例患者行支架置入的输尿管-肠吻合术,122 例患者行无支架输尿管-肠吻合术。90 天总并发症、高级别并发症、再入院、尿路感染、漏尿和肠梗阻的发生率无显著差异(>0.05)。支架组输尿管-肠吻合口狭窄的发生率在 1 年和 2 年时分别为 13%和 18%,而无支架组分别为 7%和 10%(=0.05)。支架放置与输尿管-肠吻合口狭窄显著相关。

结论

RARC 和回肠导管后行无支架输尿管-肠吻合术与较少的狭窄相关。

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