Bueno Morón Jorge, Arbore Federica, van Klink Gerard P M, Mascal Mark, Gruter Gert-Jan M
Van 't Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 904, 1090 GD, Amsterdam, The Netherlands.
Avantium Chemicals BV, Zekeringstraat 29, 1014 BV, Amsterdam, The Netherlands.
ChemSusChem. 2024 Oct 21;17(20):e202400495. doi: 10.1002/cssc.202400495. Epub 2024 Aug 2.
The synthesis of 5-(halomethyl)furfurals (XMFs, X=F, Cl, Br, I), including 5-(chloromethyl)furfural (CMF), 5-(bromomethyl)furfural (BMF), 5-(iodomethyl)furfural (IMF), and 5-(fluoromethyl)furfural (FMF), from biomass represents a pivotal advancement in renewable chemistry and engineering. Harnessing waste biomass as a raw material offers a sustainable alternative to fossil-based resources, mitigating environmental degradation and addressing pressing energy needs. CMF and BMF, characterized by their enhanced stability over the hydroxyl analog, 5-(hydroxymethyl)furfural (HMF), exhibit promise as renewable building blocks for scale-up and commercialization. The surge in research interest, particularly from 2010 to 2024, reflects a growing recognition of XMFs' potential as novel platform chemicals. This review highlights the evolution of XMF synthesis methods, focusing on their transformation from saccharides and lignocellulosic biomass. Mechanistic insights and experimental setups are scrutinized for industrial feasibility and scalability, shedding light on technical challenges and avenues for further research. The analysis underscores the burgeoning significance of XMFs in the transition towards sustainable chemical production, emphasizing the importance of process optimization and mechanistic understanding for commercial deployment.
从生物质合成5-（卤甲基）糠醛（XMFs，X = F、Cl、Br、I），包括5-（氯甲基）糠醛（CMF）、5-（溴甲基）糠醛（BMF）、5-（碘甲基）糠醛（IMF）和5-（氟甲基）糠醛（FMF），是可再生化学与工程领域的一项关键进展。利用废弃生物质作为原料，为基于化石的资源提供了一种可持续的替代方案，减轻了环境退化并满足了紧迫的能源需求。CMF和BMF相较于其羟基类似物5-（羟甲基）糠醛（HMF）具有更高的稳定性，有望成为用于扩大规模和商业化的可再生基础材料。研究兴趣的激增，尤其是在2010年至2024年期间，反映出人们越来越认识到XMFs作为新型平台化学品的潜力。本综述重点介绍了XMF合成方法的演变，着重于它们从糖类和木质纤维素生物质的转化。对工业可行性和可扩展性的机理见解和实验设置进行了审视，揭示了技术挑战和进一步研究的途径。分析强调了XMFs在向可持续化化学品生产转型过程中日益凸显的重要性，强调了工艺优化和机理理解对于商业应用的重要性。
