SUMMARY is divided into two subspecies, subsp. (renamed in 1992; ATCC 49326) and subsp. (ATCC 27840), and fits with the archetype of clinically relevant coagulase-negative staphylococci (CoNS). is a commensal bacterium of the skin in humans, which must be considered an opportunistic pathogen of interest particularly as soon as it is identified in a clinically relevant specimen from an immunocompromised patient. Several studies have highlighted the potential determinants underlying pathogenicity, resistance profiles, and virulence factors. In addition, mobile genetic element acquisitions and mutations contribute to genome adaptation to its environment. Over the past decades, antibiotic resistance has been identified for in almost all the families of the currently available antibiotics and is related to the emergence of multidrug-resistant clones of high clinical significance. The present review summarizes the current knowledge concerning the taxonomic position of among staphylococci, the involvement of this species in human colonization and diseases, the virulence factors supporting its pathogenicity, and the phenotypic and genomic antimicrobial resistance profiles of this species.