行为激活游戏疗法对青少年抑郁症的疗效：一项随机对照试验研究方案。
The effect of behavioral activation play therapy in adolescents with depression: A study protocol for a randomized controlled trial.
机构信息
The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China.
Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China.
出版信息
PLoS One. 2024 Jun 20;19(6):e0304084. doi: 10.1371/journal.pone.0304084. eCollection 2024.
BACKGROUND
Depression is a common psychological problem in adolescents worldwide. Although the World Health Organization recommends that members of this population engage in physical activity to reduce depressive symptoms, compliance with this recommendation is often low. Furthermore, although behavioral activation (BA) is recommended as a treatment for adolescents with depression, the reported effect size is small. Compared with traditional exercises, gamified physical activity (GPA) can be particularly appealing to adolescents because it is perceived as an enjoyable experience. In this study, we integrated BA and GPA to create behavioral activation play therapy (BAPT). We designed a clinical trial to investigate the feasibility, acceptability, and effectiveness of this treatment in adolescents with depression.
METHODS
This study is a randomized controlled trial (RCT) with a three-arm, assessor-blinded design, conducted to validate the effectiveness and applicability of BAPT for treating adolescent with depression. We will recruit 258 participants and randomly assign them to a BAPT group, BA group, or GPA group using a ratio of 1:1:1. Based on conventional strategies for treatment and care, the three groups will receive nine BAPT sessions, nine BA sessions, or nine GPA sessions, respectively. We will compare the outcomes of the BAPT with those of the BA and GPA interventions.
DISCUSSION
This is the first RCT to explore the effectiveness and applicability of BAPT in adolescents with depression. This study will provide evidence that may help to decrease depressive symptoms in adolescents, and will demonstrate the treatment effectiveness in terms of increasing levels of physical activity, reducing the rate of non-suicidal self-injury behaviors, and improving sleep quality. We will also assess the presence of side effects and the treatment adherence of patients receiving BAPT.
TRIAL REGISTRATION
Trial registration: Chinese Clinical Trial Registry, ChiCTR2300072671. Registered on 20 June 2023.
背景
抑郁是全球青少年中常见的心理问题。尽管世界卫生组织建议该人群进行身体活动以减轻抑郁症状，但对这一建议的依从性往往较低。此外，尽管行为激活（BA）被推荐作为治疗青少年抑郁症的方法，但报告的效应量很小。与传统运动相比，游戏化身体活动（GPA）对青少年更具吸引力，因为它被视为一种愉快的体验。在本研究中，我们将 BA 和 GPA 相结合，创建了行为激活游戏治疗（BAPT）。我们设计了一项临床试验，以调查该治疗方法在青少年抑郁症患者中的可行性、可接受性和有效性。
方法
这是一项随机对照试验（RCT），采用三臂、评估者盲法设计，旨在验证 BAPT 治疗青少年抑郁症的有效性和适用性。我们将招募 258 名参与者，并按照 1:1:1 的比例将他们随机分配到 BAPT 组、BA 组或 GPA 组。基于传统的治疗和护理策略，三组将分别接受九次 BAPT 治疗、九次 BA 治疗或九次 GPA 治疗。我们将比较 BAPT 的结果与 BA 和 GPA 干预的结果。
讨论
这是第一项探索 BAPT 在青少年抑郁症患者中的有效性和适用性的 RCT。本研究将提供有助于减少青少年抑郁症状的证据，并证明在增加身体活动水平、降低非自杀性自伤行为发生率和改善睡眠质量方面的治疗效果。我们还将评估接受 BAPT 治疗的患者的副作用和治疗依从性。
试验注册
临床试验注册：中国临床试验注册中心，ChiCTR2300072671。于 2023 年 6 月 20 日注册。
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