Mental Health Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
School of Clinical Medicine, Sichuan University, Chengdu, 610041, China.
BMC Psychiatry. 2023 Jul 13;23(1):507. doi: 10.1186/s12888-023-04967-7.
Depression is a condition that imposes a significant disease burden, with cognitive impairment being one of its costly symptoms. While cognitive rehabilitation is crucial, it is also challenging. Although some studies have investigated the impact of exergames on cognitive function improvement, these have primarily focused on the elderly population, with limited attention given to individuals with depression. Consequently, this study aims to investigate the effects of exergames on cognitive functions in adolescents with depression and compare the effectiveness of exergames with traditional exercise.
The present investigation is a single-center randomized controlled trial that employs the ANOVA method to calculate the sample size using G*Power software, assuming a 25% dropout rate. The study enrolls fifty-four eligible patients with depression who are randomly allocated to one of three treatment groups: the exergames group, which receives standard treatment and exergames intervention; the exercise group, which receives standard treatment and traditional exercise intervention; and the control group, which receives standard treatment exclusively. The study provides a comprehensive regimen of 22 supervised exercise and exergame sessions over an 8-week period, with a frequency of twice per week for the initial two weeks and three times per week for the subsequent six weeks. The researchers gather cognitive, mood, and sleep metrics at the onset of the first week, as well as at the conclusion of the fourth and eighth weeks. The researchers employ a wearable device to track participants' heart rate during each intervention session and evaluate the Borg Rating of Perceived Exertion scale at the conclusion of each session.
The findings from this study make several contributions to the current literature. First, this study comprehensively reports the efficacy of an exergames intervention for multidimensional symptoms in adolescents with depression. Second, this study also compares the efficacy of exergames with that of traditional exercise. These findings provide a theoretical basis for the use of exergames as an adjunctive intervention for depression and lay the groundwork for future research.
This trial is registered with the Chinese Clinical Trials Registry (Registration number: ChiCTR2100052709; Registration Status: Prospective registration;) 3/11/2021, URL: http://www.chictr.org.cn/edit.aspx?pid=135663&htm=4 .
抑郁症是一种会造成严重疾病负担的疾病，认知障碍是其代价高昂的症状之一。虽然认知康复至关重要，但也极具挑战性。虽然一些研究已经调查了运动游戏对认知功能改善的影响，但这些研究主要集中在老年人群体，而对抑郁症患者的关注有限。因此，本研究旨在调查运动游戏对抑郁症青少年认知功能的影响，并比较运动游戏与传统运动的效果。
本研究是一项单中心随机对照试验，采用方差分析方法，使用 G*Power 软件计算样本量，假设 25%的脱落率。研究纳入 54 名符合条件的抑郁症患者，随机分为三组治疗组：运动游戏组，接受标准治疗和运动游戏干预；运动组，接受标准治疗和传统运动干预；对照组，仅接受标准治疗。研究提供了一个全面的方案，包括 22 次监督运动和运动游戏课程，在 8 周内进行，前两周每周两次，后六周每周三次。研究人员在第一周开始时以及第四周和第八周结束时收集认知、情绪和睡眠指标。研究人员在每次干预期间使用可穿戴设备跟踪参与者的心率，并在每次干预结束时评估 Borg 感知用力量表。
本研究的结果为当前文献做出了几项贡献。首先，本研究全面报告了运动游戏干预对青少年抑郁症多维症状的疗效。其次，本研究还比较了运动游戏与传统运动的效果。这些发现为运动游戏作为抑郁症辅助干预的应用提供了理论依据，并为未来的研究奠定了基础。
本试验在中国临床试验注册中心注册（注册号：ChiCTR2100052709；注册状态：前瞻性注册）；2021 年 3 月 11 日；网址：http://www.chictr.org.cn/edit.aspx?pid=135663&htm=4 。
