Sampath Ashwath Jonathan, Westerkam Linnea L, Blum Franklin R, Alhusayen Raed, Bechara Falk G, Caffrey Julie, Carmona-Rivera Carmelo, Chandran Nisha Suyien, George Ralph, Goldberg Stephanie R, Gudjonsson Johann E, Hansen Scott L, Ingram John R, Kirby Brian, Marzano Angelo Valerio, Matusiak Łukasz, Orgill Dennis P, Prens Errol, van der Zee Hessel H, van Straalen Kelsey R, Zouboulis Christos C, Byrd Angel S, Frew John W, Lowes Michelle Anne, Naik Haley B, Sokumbi Olayemi, Mi Qing-Sheng, Miedema Jayson R, Googe Paul B, Sayed Christopher J
Department of Dermatology, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
J Invest Dermatol. 2025 Jan;145(1):50-55. doi: 10.1016/j.jid.2024.02.041. Epub 2024 Jun 18.
Methods for describing and reporting the clinical and histologic characteristics of cutaneous tissue samples from patients with hidradenitis suppurativa (HS) are not currently standardized, limiting clinicians' and scientists' ability to uniformly record, report, and communicate about the characteristics of tissue used in translational experiments. A recently published consensus statement outlined morphological definitions of typical HS lesions, but no consensus has been reached regarding clinical characterization and examination of HS tissue samples. In this study, we aimed to establish a protocol for reporting histopathologic and clinical characteristics of HS tissue specimens. This study was conducted from May 2023 to August 2023. Experts in clinical care, dermatopathology, and translational research were recruited, and a modified Delphi technique was used to develop a protocol for histologic reporting and clinical characterization of submitted tissue specimens from patients with HS. A total of 27 experts participated (14 dermatologists, 3 fellowship-trained dermatopathologists, 3 plastic surgeons, 3 general surgeons, and 4 research scientists) in creating and reviewing protocols for the clinical and histopathological examination of HS tissue specimens. The protocols were formatted as a synoptic report and will help to consistently classify specimens in biobanks on the basis of histologic features and more accurately report and select samples used in translational research projects.
目前，描述和报告化脓性汗腺炎（HS）患者皮肤组织样本的临床和组织学特征的方法尚未标准化，这限制了临床医生和科学家统一记录、报告和交流转化实验中所用组织特征的能力。最近发表的一份共识声明概述了典型HS病变的形态学定义，但在HS组织样本的临床特征描述和检查方面尚未达成共识。在本研究中，我们旨在建立一个报告HS组织标本组织病理学和临床特征的方案。本研究于2023年5月至2023年8月进行。招募了临床护理、皮肤病理学和转化研究方面的专家，并采用改良的德尔菲技术制定了一份关于提交的HS患者组织标本组织学报告和临床特征描述的方案。共有27名专家参与（14名皮肤科医生、3名接受过专科培训的皮肤病理学家、3名整形外科医生、3名普通外科医生和4名研究科学家）创建和审查HS组织标本临床和组织病理学检查的方案。这些方案以概要报告的形式呈现，将有助于根据组织学特征对生物样本库中的标本进行一致分类，并更准确地报告和选择转化研究项目中使用的样本。
