Department of Health Promotion and Child Care, Internal Medicine and Medical Specialties, Università degli Studi di Palermo, Palermo, Italy.
Fondazione Istituto "G. Giglio" Cefalù, Palermo, Italy.
Clin Hemorheol Microcirc. 2024;88(2):199-209. doi: 10.3233/CH-221422.
Asymptomatic atherosclerosis is an important early marker of vascular damage and, among its risk factors, hemorheological alterations play an important role.
In a cohort of 85 non-diabetic subjects with asymptomatic carotid atherosclerosis (ACA), we have measured whole blood viscosity (cWBV) according to the haematocrit and plasma fibrinogen level. The cWBV distinguish the subgroup of ACA subjects with 3-5 cardiovascular risk factors (CRFs) from that with 1-2 CRFs and the same behavior is present for haematocrit and plasma fibrinogen level. Therefore, we divided the whole group of ACA subjects according to the medians of the four surrogate indexes with an insulin resistance degree of TG/HDL-C, TyG, VAI and LAP.
The analysis of the correlation between cWBV and each index of insulin resistance has shown that no correlation is present in the whole group and in the group of ACA subjects with 1-2 CRFs, while in the subgroup with 3-5 CRFs there is a positive correlation between cWBV with TG/HDL-C and TyG at a low degree of statistical significance.
The date underline that subjects with this clinical condition have an unaltered evaluation of the cWBV compared to the other indices.
无症状性动脉粥样硬化是血管损伤的一个重要早期标志物，在其危险因素中，血液流变学改变起着重要作用。
在 85 例非糖尿病无症状性颈动脉粥样硬化（ACA）患者的队列中，我们根据红细胞压积和血浆纤维蛋白原水平测量了全血黏度（cWBV）。cWBV 可区分具有 3-5 个心血管危险因素（CRFs）的 ACA 患者亚组与具有 1-2 个 CRFs 的亚组，红细胞压积和血浆纤维蛋白原水平也存在相同的行为。因此，我们根据 TG/HDL-C、TyG、VAI 和 LAP 的胰岛素抵抗程度的四个替代指标的中位数将整个 ACA 患者组进行了分组。
cWBV 与胰岛素抵抗各指标之间的相关性分析表明，在整个组和具有 1-2 个 CRFs 的 ACA 患者组中没有相关性，而在具有 3-5 个 CRFs 的亚组中，cWBV 与 TG/HDL-C 和 TyG 之间存在低度统计学意义的正相关。
这些数据表明，与其他指标相比，具有这种临床情况的患者的 cWBV 评估没有改变。
