Carallo C, Pujia A, Irace C, De Franceschi M S, Motti C, Gnasso A
Dipartimento di Medicina Sperimentale e Clinica, Centro Aterosclerosi, University of Reggio Calabria, Catanzaro, Italy.
Coron Artery Dis. 1998;9(2-3):113-7.
Alterations in blood viscosity and haematocrit have been described in patients with coronary and cerebrovascular diseases. The results have not been conclusive, as modifications of these parameters are often associated with the presence of coronary heart disease (CHD) risk factors. The aim of this study was to verify whether blood viscosity and haematocrit are increased in patients with carotid atherosclerosis, independently of the presence of CHD risk factors.
Male patients with internal carotid atherosclerosis (ICA+, n = 28) were selected from participants in a cardiovascular disease prevention campaign. Controls (ICA-, n = 28), also participating in the prevention campaign, were matched for age and all the classical CHD risk factors. Plasma lipids, glucose and fibrinogen were determined by routine methods. Cigarette smoking and current drug therapy was established by questionnaire. Whole blood viscosity was measured at shear rates of 450 and 225/s, using a cone-plate viscometer. Echo-Doppler of carotid arteries was performed with an ATL Ultramark 9 HDI using a 5-10 MHz multifrequency probe.
Blood pressure, plasma lipids, glucose, body mass index, fibrinogen and plasma viscosity were similar in the two groups. ICA+ patients, compared with the ICA- group, had significantly greater values of blood viscosity (4.52 +/- 0.37 cP compared with 4.18 +/- 0.45 cP, P < 0.005 respectively; shear rate 450/s) and haematocrit (48.57 +/- 3.19% compared with 45.57 +/- 4.81%, P < 0.008 respectively).
Our findings demonstrate that blood viscosity and haematocrit are increased in men with internal carotid atherosclerosis, independently of the presence of risk factors for atherosclerosis.
在患有冠状动脉疾病和脑血管疾病的患者中，已观察到血液粘度和血细胞比容的改变。但结果尚无定论，因为这些参数的变化常与冠心病（CHD）危险因素的存在有关。本研究的目的是验证在颈动脉粥样硬化患者中，血液粘度和血细胞比容是否会升高，而与CHD危险因素的存在无关。
从心血管疾病预防活动的参与者中选取患有颈内动脉粥样硬化的男性患者（ICA +，n = 28）。同样参与预防活动的对照组（ICA -，n = 28）在年龄和所有经典的CHD危险因素方面进行了匹配。通过常规方法测定血脂、血糖和纤维蛋白原。通过问卷调查确定吸烟情况和当前药物治疗情况。使用锥板式粘度计在450和225/s的剪切速率下测量全血粘度。使用5 - 10 MHz多频探头，通过ATL Ultramark 9 HDI对颈动脉进行超声多普勒检查。
两组患者的血压、血脂、血糖、体重指数、纤维蛋白原和血浆粘度相似。与ICA -组相比，ICA +组患者的血液粘度（分别为4.52 +/- 0.37 cP和4.18 +/- 0.45 cP，P < 0.005；剪切速率450/s）和血细胞比容（分别为48.57 +/- 3.19%和45.57 +/- 4.81%，P < 0.008）显著更高。
我们的研究结果表明，患有颈内动脉粥样硬化的男性患者血液粘度和血细胞比容升高，与动脉粥样硬化危险因素的存在无关。
