Department of Advanced Materials, Hannam University, Yuseonggu, Daejeon, Korea.
Youngjin DNT, Hwaseong, Gyeonggido, Korea.
Clin Hemorheol Microcirc. 2024;88(2):211-219. doi: 10.3233/CH-242256.
The greater the viscosity of the blood, the more difficult its flow becomes, leading to an increased incidence of diseases caused by blood circulation disorders. These diseases are commonly associated with the cardiovascular and cerebrovascular systems. High blood viscosity is a primary cause of circulatory system diseases. Studies have shown that accurately measuring blood viscosity and applying this data in clinical trials can help prevent circulatory system diseases. Viscosity data can vary depending on the measurement methods used, even when these methods are based on hydrodynamic principles. Despite using approved blood viscometers, the results often differ depending on the type of viscometer used, potentially causing confusion within the medical field. Informing the medical community about these differences and the level of error associated with each measurement method can help reduce this confusion. To our knowledge, the degree of difference in viscosity measurement results due to different measurement methods and the reasons for these differences have not yet been thoroughly explored. In this study, we selected three blood viscosity measurement methods registered with the Ministry of Food and Drug Safety of Korea to analyze the same canine blood. The viscosity measurements were carried out using each device and compared. The parallel plate and scanning capillary methods yielded similar viscosity values, while the cone plate method showed lower viscosity values. The viscosity of blood, as measured by the three viscometers, differed, indicating that more experimental data must be accumulated to evaluate the cause of these differences. In this paper, we identified several causes of inconsistency and suggested measures to avoid this confusion. However, confirming that the test results show systematic differences is expected to assist clinicians who diagnose and prescribe treatments based on blood viscosity results. The findings of this comparative study are anticipated to serve as a starting point for establishing guidelines or standards for blood viscosity measurement methods.
血液的黏度越大,其流动就越困难,从而导致血液循环障碍引起的疾病的发病率增加。这些疾病通常与心血管和脑血管系统有关。血液黏度高是循环系统疾病的主要原因。研究表明,准确测量血液黏度并将这些数据应用于临床试验有助于预防循环系统疾病。黏度数据可能因所使用的测量方法而异,即使这些方法基于流体动力学原理。尽管使用了经过批准的血液黏度计,但结果仍可能因所使用的黏度计类型而异,这可能会在医学界引起混淆。向医学界通报这些差异以及每种测量方法所涉及的误差水平有助于减少这种混淆。据我们所知,由于不同的测量方法,黏度测量结果的差异程度以及造成这些差异的原因尚未得到充分探讨。在这项研究中,我们选择了三种在韩国食品医药品安全处注册的血液黏度测量方法来分析相同的犬血。使用每种设备进行黏度测量并进行比较。平行板和扫描毛细管法得出的黏度值相似,而锥板法显示的黏度值较低。三种黏度计测量的血液黏度不同,这表明需要积累更多的实验数据来评估这些差异的原因。在本文中,我们确定了导致不一致的几个原因,并提出了避免这种混淆的措施。然而,确认测试结果显示出系统性差异有望帮助根据血液黏度结果进行诊断和处方治疗的临床医生。这项比较研究的结果有望为建立血液黏度测量方法的指南或标准提供起点。