Department of Food Science and Nutrition, Keimyung University, Daegu, 42601, South Korea.
Department of Food Science and Nutrition, Keimyung University, Daegu, 42601, South Korea.
Appetite. 2024 Sep 1;200:107561. doi: 10.1016/j.appet.2024.107561. Epub 2024 Jun 20.
Genetic variation in the bitter taste receptor gene taste receptor type 2, member 38 (TAS2R38) is associated with an individual's bitter taste sensitivity, food preference and consumption, which may also influence overall diet quality. This study aims to determine whether the TAS2R38 bitter taste receptor genetic variation is associated with overall diet quality using the Korean Healthy Eating Index (KHEI). A total of 41,839 individuals from the Korean Genome and Epidemiology Study were analyzed for their TAS2R38 diplotypes (rs713598, rs1726866, and rs10246939), general characteristics, and KHEI scores by obesity status. Results revealed that in the non-obese group, individuals with the AVI/AVI diplotype had a significantly higher score of 'ratio of white meat to red meat' than individuals with the PAV/* diplotype (3.89 ± 3.23 vs. 3.79 ± 3.18, adjusted p = 0.029). However, obese individuals with the PAV/* diplotype showed a significantly higher level of the mean score of 'moderation' (19.32 ± 5.82 vs. 18.92 ± 5.80, adjusted p = 0.026) and total KHEI score (61.07 ± 12.19 vs. 60.52 ± 12.29, adjusted p = 0.008) than those with the AVI/AVI diplotype. Finally, an interactive effect between bitterness genetic variation and obesity level was observed in those scores of 'ratio of white meat to red meat' (adjusted p = 0.007), 'moderation' (adjusted p = 0.013), and total KEHI (adjusted p = 0.007). In conclusion, TAS2R38 genetic variation is associated with overall diet quality in Koreans, which is more evident in the obese group.
苦味受体基因 TAS2R38 中的遗传变异与个体的苦味敏感度、食物偏好和消费有关，这也可能影响整体饮食质量。本研究旨在使用韩国健康饮食指数（KHEI）确定 TAS2R38 苦味受体遗传变异是否与整体饮食质量有关。对来自韩国基因组和流行病学研究的 41839 名个体进行了 TAS2R38 二倍型（rs713598、rs1726866 和 rs10246939）、一般特征和 KHEI 评分分析，按肥胖状况进行分组。结果显示，在非肥胖组中，AVI/AVI 二倍型个体的“白肉与红肉比例”评分显著高于 PAV/* 二倍型个体（3.89±3.23 与 3.79±3.18，调整后的 p=0.029）。然而，肥胖个体的 PAV/* 二倍型在“适度”的平均评分（19.32±5.82 与 18.92±5.80，调整后的 p=0.026）和总 KHEI 评分（61.07±12.19 与 60.52±12.29，调整后的 p=0.008）方面显著高于 AVI/AVI 二倍型个体。最后，在这些评分中观察到苦味遗传变异与肥胖程度之间存在交互作用，如“白肉与红肉比例”（调整后的 p=0.007）、“适度”（调整后的 p=0.013）和总 KHEI（调整后的 p=0.007）。综上所述，TAS2R38 遗传变异与韩国人的整体饮食质量有关，在肥胖人群中更为明显。
