State Key Laboratory of Mariculture Breeding, Key Laboratory of Marine Biotechnology of Fujian Province, Fujian Agriculture and Forestry University, Fuzhou 350002, China; College of Food Science and Engineering, South China University of Technology, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou 510642, China; Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA.
State Key Laboratory of Mariculture Breeding, Key Laboratory of Marine Biotechnology of Fujian Province, Fujian Agriculture and Forestry University, Fuzhou 350002, China; College of Food Science and Engineering, South China University of Technology, Guangzhou 510006, China.
Int J Biol Macromol. 2024 Aug;274(Pt 1):133279. doi: 10.1016/j.ijbiomac.2024.133279. Epub 2024 Jun 19.
Resistant starch (RS) can potentially prevent type 2 diabetes through the modulation of intestinal microbiota and microbial metabolites. Currently, it has been wildly noted that altering the intestinal microbial composition and short-chain fatty acids levels can achieve therapeutic effects, although the specific mechanisms were rarely elucidated. This review systematically explores the structural characteristics of different RS, analyzes the cross-feeding mechanism utilized by intestinal microbiota, and outlines the pathways and targets of butyrate, a primary microbial metabolite, for treating diabetes. Different RS types may have a unique impact on microbiota composition and their cross-feeding, thus exploring regulatory mechanisms of RS on diabetes through intestinal flora interaction and their metabolites could pave the way for more effective treatment outcomes for host health. Furthermore, by understanding the mechanisms of strain-level cross-feeding and metabolites of RS, precise dietary supplementation methods targeted at intestinal composition and metabolites can be achieved to improve T2DM.
抗性淀粉（RS）可以通过调节肠道微生物群和微生物代谢物来预防 2 型糖尿病。目前，人们广泛注意到，改变肠道微生物组成和短链脂肪酸水平可以达到治疗效果，尽管具体机制很少被阐明。本综述系统地探讨了不同 RS 的结构特征，分析了肠道微生物群利用的交叉喂养机制，并概述了丁酸作为主要微生物代谢物治疗糖尿病的途径和靶点。不同类型的 RS 可能对微生物群落组成及其交叉喂养有独特的影响，因此，通过肠道菌群相互作用及其代谢物来探索 RS 对糖尿病的调节机制，可以为宿主健康的更有效治疗结果铺平道路。此外，通过了解 RS 的菌株水平交叉喂养和代谢物的机制，可以实现针对肠道组成和代谢物的精确饮食补充方法，以改善 T2DM。
