College of Food Science and Engineering, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi Province 712100, People's Republic of China.
Food Funct. 2020 Jul 22;11(7):5749-5767. doi: 10.1039/d0fo00855a.
Resistant starch (RS) is well known to prevent type 2 diabetes mellitus (T2DM) and obesity. Recently, attention has been paid to gut microbiota which mediates the RS's impact on T2DM and obesity, while a mechanistic understanding of how RS prevents T2DM and obesity through gut microbiota is not clear yet. Therefore, this review aims at exploring the underlying mechanisms of it. RS prevents T2DM and obesity through gut microbiota by modifying selective microbial composition to produce starch-degrading enzymes, promoting the production of intestinal metabolites, and improving gut barrier function. Therefore, RS possessing good functional features can be used to increase the fiber content of healthier food. Furthermore, achieving highly selective effects on gut microbiota based on the slight differences of RS's chemical structure and focusing on the effects of RS on strain-levels are essential to manipulate the microbiota for human health.
抗性淀粉（RS）是众所周知的预防 2 型糖尿病（T2DM）和肥胖症。最近，人们对肠道微生物群产生了关注，它介导了 RS 对 T2DM 和肥胖症的影响，而 RS 通过肠道微生物群预防 T2DM 和肥胖症的机制尚不清楚。因此，本综述旨在探讨其潜在机制。RS 通过改变选择性微生物组成来产生淀粉降解酶，促进肠道代谢物的产生，并改善肠道屏障功能，从而通过肠道微生物群来预防 T2DM 和肥胖症。因此，具有良好功能特性的 RS 可以用于增加更健康食品的纤维含量。此外，基于 RS 的化学结构的细微差异，实现对肠道微生物群的高度选择性作用，并关注 RS 对菌株水平的影响，对于操纵微生物群以促进人类健康至关重要。
