Wicker P, Dallocchio M
Ann Cardiol Angeiol (Paris). 1985 Apr 30;34(4 Pt 2):253-8.
The concept of labile hypertension (also called borderline hypertension) has been proposed to define those patients in whom blood pressure is sometimes below, sometimes above the frontier which separates normal and high blood pressure. Current evidence does not support the individualization of this concept, since numerous studies have demonstrated a similar or even higher blood pressure variability in hypertensive patients than that found in normotensive patients. The main objective, when measuring blood pressure, is to assess the risk of a cardiovascular event. It has been shown that the average value of several blood pressure determinations provides a better estimate of cardiovascular risk, and correlates better with hypertensive target organ disease, than a single blood pressure measurement. Therefore, we propose to define these so-called labile hypertensive patients on the basis of the average and to classify them into the category of mild hypertension, the later being defined as a diastolic blood pressure between 90 and 105 mmHg on several occasions according to the WHO. The increase in cardiovascular risk carried by a mild elevation in blood pressure, either untreated or treated with general health measures, is small, approximately 3% per year. Moreover, whereas the beneficial effects of pharmacological antihypertensive therapy have been demonstrated on a whole population basis, these effects remain controversial on an individual basis. Thus, it appears justified to give these hypertensive patients general health measures advice without any pharmacological therapy during the first months of follow-up. During this time, blood pressure measurements are repeated so that blood pressure status, and thus the need for pharmacological therapy, can be assessed more precisely.
不稳定高血压(也称为临界高血压)这一概念已被提出,用于定义那些血压有时低于、有时高于区分正常血压和高血压界限的患者。目前的证据并不支持这一概念的个体化,因为大量研究表明,高血压患者的血压变异性与血压正常者相似,甚至更高。测量血压的主要目的是评估心血管事件的风险。研究表明,多次血压测定的平均值比单次血压测量能更好地估计心血管风险,并且与高血压靶器官疾病的相关性更强。因此,我们建议根据平均值来定义这些所谓的不稳定高血压患者,并将他们归类为轻度高血压,根据世界卫生组织的标准,轻度高血压定义为多次测量时舒张压在90至105 mmHg之间。血压轻度升高,无论未经治疗还是采用一般健康措施治疗,所带来的心血管风险增加都很小,每年约为3%。此外,虽然药理学降压治疗对整个人群的有益效果已得到证实,但在个体层面上这些效果仍存在争议。因此,在随访的最初几个月,对这些高血压患者给予一般健康措施建议而不进行任何药物治疗似乎是合理的。在此期间,重复测量血压,以便更精确地评估血压状况,从而确定是否需要药物治疗。