Department of Histology and Embryology, School of Medicine, Shaoxing University, Shaoxing, 312000, Zhejiang Province, China.
Neuromolecular Med. 2024 Jun 21;26(1):26. doi: 10.1007/s12017-024-08794-1.
Spinal cord injury (SCI) causes irreversible cell loss and neurological dysfunctions. Presently, there is no an effective clinical treatment for SCI. It can be the only intervention measure by relieving the symptoms of patients such as pain and fever. Free radical-induced damage is one of the validated mechanisms in the complex secondary injury following primary SCI. Hydrogen sulfide (HS) as an antioxidant can effectively scavenge free radicals, protect neurons, and improve SCI by inhibiting the p38MAPK/mTOR/NF-κB signaling pathway. In this report, we analyze the pathological mechanism of SCI, the role of free radical-mediated the p38MAPK/mTOR/NF-κB signaling pathway in SCI, and the role of HS in scavenging free radicals and improving SCI.
脊髓损伤 (SCI) 会导致不可逆转的细胞死亡和神经功能障碍。目前，SCI 没有有效的临床治疗方法。它只能通过缓解患者的疼痛和发烧等症状来作为唯一的干预措施。自由基诱导的损伤是原发性 SCI 后复杂继发性损伤的已验证机制之一。硫化氢 (HS) 作为一种抗氧化剂，可通过抑制 p38MAPK/mTOR/NF-κB 信号通路有效清除自由基、保护神经元，并改善 SCI。在本报告中，我们分析了 SCI 的病理机制、自由基介导的 p38MAPK/mTOR/NF-κB 信号通路在 SCI 中的作用以及 HS 清除自由基和改善 SCI 的作用。
